0000950170-23-062929 | 10-Q | XBRL Viewer | ALX Oncology Holdings INC

Balance Sheet Components (Tables)

9 Months Ended

Sep. 30, 2023

Balance Sheet Related Disclosures [Abstract]

Schedule of Components of Property and Equipment

The following table presents the components of property and equipment, net as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,			December 31,
	2023			2022
Leasehold improvements	$	2,513		$	2,360
Laboratory equipment		1,570			1,422
Computer hardware and software		400			344
Furniture and fixtures		166			166
Property and equipment, gross		4,649			4,292
Less: accumulated depreciation		(1,032	)		(403	)
Property and equipment, net	$	3,617		$	3,889

Schedule of Components of Other Assets, Net

The following table presents the components of other assets as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,		December 31,
	2023		2022
Operating lease right-of-use assets	$	5,044	$	5,626
Long-term prepaid clinical expenses		4,311		7,264
Finance lease right-of-use assets		1,147		298
Long-term prepaid contract manufacturing costs		272		1,456
Other		210		288
Total other assets	$	10,984	$	14,932

Components of Accrued Expenses and Other Current Liabilities

The following table presents the components of accrued expenses and other current liabilities as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,		December 31,
	2023		2022
Accrued contract manufacturing	$	11,576	$	5,249
Accrued clinical and nonclinical study costs		4,306		5,485
Accrued compensation and related expenses		4,005		3,708
Accrued property and equipment		176		2,110
Other		1,813		2,050
Total accrued expenses and other current liabilities	$	21,876	$	18,602

Commitments and Contingencies - Summary of Other Contractual Obligations and Other Commitments from Manufacturing and Service Contracts (Details) $ in Thousands	Sep. 30, 2023 USD ($)
Commitments and Contingencies Disclosure [Abstract]
Manufacturing and service contracts, Total	$ 8,822
Manufacturing and service contracts, 2023 (remaining three months)	4,114
Manufacturing and service contracts, 2024 - 2025	4,652
Manufacturing and service contracts, 2026 - 2027	56
Contractual Obligation, Total	8,822
Contractual Obligation, 2023 (remaining three months)	4,114
Contractual Obligation, 2024 - 2025	4,652
Contractual Obligation, 2026 - 2027	$ 56

Stockholders' Equity

9 Months Ended

Sep. 30, 2023

Equity [Abstract]

STOCKHOLDERS' EQUITY

(7) STOCKHOLDERS’ EQUITY

On July 21, 2020, the Company’s amended and restated certificate of incorporation became effective, authorizing 1,000,000,000 shares of common stock, $0.001 par value per share, and 100,000,000 shares of undesignated preferred stock, $0.001 par value per share. As of September 30, 2023 and December 31, 2022, the Company had 41,151,819 and 40,861,386 shares of common stock outstanding, respectively.

Common stock reserved for future issuance as of September 30, 2023 consists of the following:


	September 30, 2023
Stock options issued and outstanding		9,114,886
Stock options authorized for future issuance		1,147,137
Employee Stock Purchase Plan shares authorized for future issuance		1,095,066
Restricted stock issued and outstanding		1,084,403
Total		12,441,492

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
-Paragraph 13
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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-Subparagraph (i)
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
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Reference 19: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Leases - Additional Information (Details)	9 Months Ended
Leases - Additional Information (Details)	Sep. 30, 2023
Lessee Lease Description [Line Items]
Operating lease, description	The Company has non-cancelable operating leases for its offices located in the U.S. As of September 30, 2023, these leases expire on various dates between 2026 and 2030.
Option to extend term	Certain lease agreements include one or more options to renew, with renewal terms that can extend the lease up to two years after expiration.
Minimum
Lessee Lease Description [Line Items]
Lessee operating lease expiration year	2026
Maximum
Lessee Lease Description [Line Items]
Lessee operating lease expiration year	2030
Lessee operating lease renewal term	2 years

Term Loan

9 Months Ended

Sep. 30, 2023

Debt Disclosure [Abstract]

TERM LOAN

(6) TERM LOAN

Oxford Finance and Silicon Valley Bank Loan

In October 2022, the Company entered into a loan and security agreement, or the Loan Agreement, with Oxford Finance LLC, Oxford Finance Credit Fund II LP, and Silicon Valley Bank, or SVB, collectively the Lenders, for a secured term loan facility of up to $100.0 million. Pursuant to the Loan Agreement, the Company drew an initial loan of $10.0 million and has access to draw an additional $40.0 million through the end of 2023. The Loan Agreement provides for an additional $50.0 million over three tranches, with $12.5 million available in each of two tranches based upon the achievement of milestones related to the development of evorpacept and one preclinical product candidate, and $25.0 million at the Lenders’ sole discretion. The proceeds of the loans may be used by the Company for working capital and to fund its general business requirements.

Additional information regarding our indebtedness is included in our notes to our consolidated financial statements in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022, which was filed with the SEC on March 9, 2023.

The Company received net proceeds from issuance of the term loan of $9.3 million after deducting debt issuance costs of approximately $0.7 million. Debt issuance costs were recorded as debt discount on the term loan, offsetting term loan, non-current on the consolidated balance sheet. The debt discount will be amortized over the term of the loan as interest expense using the effective interest method. During the three months and nine months ended September 30, 2023, interest expense incurred in connection with the Loan Agreement was $0.3 million and $0.8 million, respectively. We had no outstanding debt as of September 30, 2022 and did not incur interest expense during the three months and nine months ended September 30, 2022.

The Company determined that certain loan features were embedded derivatives requiring bifurcation and separate accounting. Those embedded derivatives were bundled together as a single, compound embedded derivative and then bifurcated and accounted for separately from the host contract. As of September 30, 2023, the value of the embedded derivative is not material, but could become material in future periods if an event of default became more probable than is currently estimated. As of September 30, 2023, we were in compliance with all financial reporting covenants under the Loan Agreement.

On March 10, 2023, SVB was closed by the California Department of Financial Protection and Innovation, which appointed the Federal Deposit Insurance Corporation, or FDIC, to act as receiver. The FDIC created Silicon Valley Bridge Bank, N.A., or SVBB, as successor to SVB. First Citizens BancShares, Inc., or First Citizens Bank, acquired SVBB from the FDIC and operates SVBB as Silicon Valley Bank, a division of First Citizens Bank, or SVB-First Citizens. Under the Loan Agreement, 50% of the funding comes from SVB, one of the three Lenders. Given the SVBB acquisition by First Citizens Bank, the Company expects SVB-First Citizens to continue to fulfill SVB’s obligations under the Loan Agreement.

On May 31, 2023, we entered into a second amendment to the Loan Agreement. The primary purpose of the second amendment was to reduce the percentage of the amount required to be held in our collateral account with SVB-First Citizens from 100% to not less than 50% of the aggregate dollar value of all our collateral accounts.

As of September 30, 2023, the future maturities under the Loan Agreement are as follows (in thousands):


	September 30, 2023
2023	$	—
2024		—
2025		435
2026		5,217
2027		4,948
Total future maturities		10,600
Less: current portion of term loan		—
Total term loan, net of current portion		10,600
Less: unamortized debt issuance costs		(835	)
Less: unaccreted final payment costs		(190	)
Term loan, non-current, net	$	9,575

- Definition

The entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1B
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1B

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(c))
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-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
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-URI https://asc.fasb.org//470/tableOfContent

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1C

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1E

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1I

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Operating activities
Net loss	$ (115,333)	$ (92,773)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	629	237
Non-cash lease costs	920	816
Stock-based compensation	19,552	17,544
Net amortization of premiums and accretion of discounts on investments	(4,606)	(256)
Accretion of term loan discount and issuance costs	186
Changes in operating assets and liabilities
Prepaid expenses and other current assets	(4,310)	(2,613)
Other assets	4,215	(267)
Accounts payable	4,942	2,052
Payable and accrued liabilities due to related party	(1,385)	1,129
Accrued expenses and other current liabilities	6,491	6,412
Other non-current liabilities	(1,987)	(836)
Net cash used in operating activities	(90,686)	(68,555)
Investing activities
Purchase of investments	(171,619)	(315,820)
Maturities of investments	234,068	70,500
Purchase of property and equipment	(1,126)	(1,038)
Net cash provided by (used in) investing activities	61,323	(246,358)
Financing activities
Proceeds from exercise of stock options under equity incentive plan	112	345
Proceeds from issuance of common stock under employee stock purchase plan	338	302
Principal payments on finance leases	(325)	(281)
Net cash provided by financing activities	125	366
Net increase (decrease) in cash, cash equivalents and restricted cash	(29,238)	(314,547)
Cash, cash equivalents and restricted cash at beginning of year	48,888	363,667
Cash, cash equivalents and restricted cash at end of period	19,650	49,120
Supplemental disclosure of non-cash investing and financing activities
Purchase of property and equipment in accounts payable and accrued expenses	1,376	876
Right-of-use asset acquired under operating leases		4,684
Right-of-use asset acquired under finance leases	1,187
Reconciliation of cash and cash equivalents and restricted cash:
Cash and cash equivalents	19,584	49,054
Restricted cash (included in other assets)	66	66
Total cash and cash equivalents and restricted cash	$ 19,650	$ 49,120

Net Loss Per Share

9 Months Ended

Sep. 30, 2023

Earnings Per Share [Abstract]

NET LOSS PER SHARE

(10) NET LOSS PER SHARE

The following table sets forth the computation of the basic and diluted net loss per share for the three months and nine months ended September 30, 2023 and 2022 (in thousands, except share and per share data):


	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2023			2022			2023			2022
Numerator:
Net loss	$	(50,990	)	$	(35,320	)	$	(115,333	)	$	(92,773	)
Denominator:
Weighted-average shares of common stock outstanding, basic and diluted		41,147,938			40,747,026			40,963,015			40,684,172
Net loss per share, basic and diluted	$	(1.24	)	$	(0.87	)	$	(2.82	)	$	(2.28	)

Since the Company was in a loss position for all periods presented, basic net loss per share is the same as diluted net loss per share for all periods presented as the inclusion of all potential common stock outstanding would have been anti-dilutive.

The following outstanding potentially dilutive securities were excluded from the computation of diluted net loss per share for the three months and nine months ended September 30, 2023 and 2022 because including them would have been anti-dilutive:


	Three and Nine Months Ended
	September 30,
	2023		2022
Stock options issued and outstanding		9,114,886		6,214,107
Restricted stock issued and outstanding		1,084,403		870,399
Employee Stock Purchase Plan estimated shares issuable		—		21,775
Total		10,199,289		7,106,281

Fair Value of Financial Instruments - Schedule of Fair Value of Available-for-sale Investments by Contractual Maturity (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Debt Securities, Available-for-Sale, Fair Value, Fiscal Year Maturity [Abstract]
Maturing in one year or less	$ 189,528	$ 257,559
Maturing after one year through five years	6,435	16,699
Total available-for-sale investments	$ 195,963	$ 274,258

Balance Sheet Components

9 Months Ended

Sep. 30, 2023

Balance Sheet Related Disclosures [Abstract]

BALANCE SHEET COMPONENTS

(4) BALANCE SHEET COMPONENTS

Property and Equipment, Net

The following table presents the components of property and equipment, net as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,			December 31,
	2023			2022
Leasehold improvements	$	2,513		$	2,360
Laboratory equipment		1,570			1,422
Computer hardware and software		400			344
Furniture and fixtures		166			166
Property and equipment, gross		4,649			4,292
Less: accumulated depreciation		(1,032	)		(403	)
Property and equipment, net	$	3,617		$	3,889

Depreciation was $0.2 million and $0.1 million for the three months ended September 30, 2023 and 2022, respectively. Depreciation was $0.6 million and $0.2 million for the nine months ended September 30, 2023 and 2022, respectively.

Other Assets

The following table presents the components of other assets as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,		December 31,
	2023		2022
Operating lease right-of-use assets	$	5,044	$	5,626
Long-term prepaid clinical expenses		4,311		7,264
Finance lease right-of-use assets		1,147		298
Long-term prepaid contract manufacturing costs		272		1,456
Other		210		288
Total other assets	$	10,984	$	14,932

Accrued Expenses and Other Current Liabilities

The following table presents the components of accrued expenses and other current liabilities as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,		December 31,
	2023		2022
Accrued contract manufacturing	$	11,576	$	5,249
Accrued clinical and nonclinical study costs		4,306		5,485
Accrued compensation and related expenses		4,005		3,708
Accrued property and equipment		176		2,110
Other		1,813		2,050
Total accrued expenses and other current liabilities	$	21,876	$	18,602

Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit
Balance at Dec. 31, 2021	$ 363,049	$ 41	$ 564,993		$ (201,985)
Balance, shares at Dec. 31, 2021		40,587,067
Issuance of common stock under equity incentive plans	185		185
Issuance of common stock under equity incentive plans, shares		69,565
Stock-based compensation	5,501		5,501
Unrealized gain (loss) on available-for-sale investments	(606)			$ (606)
Net loss	(24,533)				(24,533)
Balance at Mar. 31, 2022	343,596	$ 41	570,679	(606)	(226,518)
Balance, shares at Mar. 31, 2022		40,656,632
Balance at Dec. 31, 2021	363,049	$ 41	564,993		(201,985)
Balance, shares at Dec. 31, 2021		40,587,067
Unrealized gain (loss) on available-for-sale investments	(1,504)
Net loss	(92,773)
Balance at Sep. 30, 2022	286,963	$ 41	583,184	(1,504)	(294,758)
Balance, shares at Sep. 30, 2022		40,748,290
Balance at Mar. 31, 2022	343,596	$ 41	570,679	(606)	(226,518)
Balance, shares at Mar. 31, 2022		40,656,632
Issuance of common stock under equity incentive plans	155		155
Issuance of common stock under equity incentive plans, shares		44,618
Issuance of common stock under employee stock purchase plan	302		302
Issuance of common stock under employee stock purchase plan, shares		44,002
Stock-based compensation	5,836		5,836
Unrealized gain (loss) on available-for-sale investments	(650)			(650)
Net loss	(32,920)				(32,920)
Balance at Jun. 30, 2022	316,319	$ 41	576,972	(1,256)	(259,438)
Balance, shares at Jun. 30, 2022		40,745,252
Issuance of common stock under equity incentive plans	5		5
Issuance of common stock under equity incentive plans, shares		3,038
Stock-based compensation	6,207		6,207
Unrealized gain (loss) on available-for-sale investments	(248)			(248)
Net loss	(35,320)				(35,320)
Balance at Sep. 30, 2022	286,963	$ 41	583,184	(1,504)	(294,758)
Balance, shares at Sep. 30, 2022		40,748,290
Balance at Dec. 31, 2022	263,464	$ 41	589,735	(845)	(325,467)
Balance, shares at Dec. 31, 2022		40,861,386
Issuance of common stock under equity incentive plans, shares		1,663
Stock-based compensation	6,351		6,351
Unrealized gain (loss) on available-for-sale investments	757			757
Net loss	(30,184)				(30,184)
Balance at Mar. 31, 2023	240,388	$ 41	596,086	(88)	(355,651)
Balance, shares at Mar. 31, 2023		40,863,049
Balance at Dec. 31, 2022	263,464	$ 41	589,735	(845)	(325,467)
Balance, shares at Dec. 31, 2022		40,861,386
Unrealized gain (loss) on available-for-sale investments	619
Net loss	(115,333)
Balance at Sep. 30, 2023	168,752	$ 41	609,737	(226)	(440,800)
Balance, shares at Sep. 30, 2023		41,151,819
Balance at Mar. 31, 2023	240,388	$ 41	596,086	(88)	(355,651)
Balance, shares at Mar. 31, 2023		40,863,049
Issuance of common stock under equity incentive plans	112		112
Issuance of common stock under equity incentive plans, shares		76,210
Issuance of common stock under employee stock purchase plan	338		338
Issuance of common stock under employee stock purchase plan, shares		52,920
Stock-based compensation	6,237		6,237
Unrealized gain (loss) on available-for-sale investments	(224)			(224)
Net loss	(34,159)				(34,159)
Balance at Jun. 30, 2023	212,692	$ 41	602,773	(312)	(389,810)
Balance, shares at Jun. 30, 2023		40,992,179
Issuance of common stock under equity incentive plans, shares		159,640
Stock-based compensation	6,964		6,964
Unrealized gain (loss) on available-for-sale investments	86			86
Net loss	(50,990)				(50,990)
Balance at Sep. 30, 2023	$ 168,752	$ 41	$ 609,737	$ (226)	$ (440,800)
Balance, shares at Sep. 30, 2023		41,151,819

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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Amount of equity (deficit) attributable to parent. Excludes temporary equity and equity attributable to noncontrolling interest.

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+ Details

Term Loan (Tables)

9 Months Ended

Sep. 30, 2023

Debt Disclosure [Abstract]

Schedule of Future Maturities Under the Loan Agreement

As of September 30, 2023, the future maturities under the Loan Agreement are as follows (in thousands):


	September 30, 2023
2023	$	—
2024		—
2025		435
2026		5,217
2027		4,948
Total future maturities		10,600
Less: current portion of term loan		—
Total term loan, net of current portion		10,600
Less: unamortized debt issuance costs		(835	)
Less: unaccreted final payment costs		(190	)
Term loan, non-current, net	$	9,575

Stock-Based Compensation - Summary of Share-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	$ 6,964	$ 6,207	$ 19,552	$ 17,544
Research and Development
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	3,728	2,931	10,011	7,696
General and Administrative
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	$ 3,236	$ 3,276	$ 9,541	$ 9,848

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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+ Details

Organization

9 Months Ended

Sep. 30, 2023

Accounting Policies [Abstract]

ORGANIZATION

(1) ORGANIZATION

Organization

ALX Oncology Holdings Inc., or the Company, was formed as a Delaware corporation on April 1, 2020, or date of inception. The Company was formed for the purpose of completing the Company’s initial public offering of its common stock and related transactions in order to carry on the business of ALX Oncology Limited. The Company is a clinical-stage immuno-oncology company focused on helping patients fight cancer by developing therapies that block the CD47 checkpoint pathway and bridge the innate and adaptive immune system.

The Company's subsidiaries include: ALX Oncology Limited, incorporated in Ireland, and a wholly-owned subsidiary of ALX Oncology Holdings Inc.; ALX Oncology Inc., incorporated in Delaware, and a wholly-owned subsidiary of ALX Oncology Limited; and Alexo International Holdings Limited, incorporated in Malta, and a wholly-owned subsidiary of ALX Oncology Inc. (collectively, the Subsidiaries).

As of September 30, 2023, the Company has devoted substantially all of its efforts to the formation and financing of the Company, as well as product development, and has not realized product revenues from its planned principal operations. The Company does not have manufacturing facilities and all manufacturing related activities are contracted out to third-party service providers.

Management expects to incur additional losses in the future to conduct product candidate research and development and pre-commercialization activities and recognizes that the Company will likely raise additional capital to fully implement its business plan. The Company intends to raise such capital through the sale of additional equity, debt financings and/or strategic alliances with third parties. However, there can be no assurance that the Company will be successful in acquiring additional funding at levels sufficient to fund its operations or on terms acceptable to the Company. If the Company is unsuccessful in its efforts to raise additional financing, the Company could be required to significantly reduce operating expenses and delay, reduce the scope of or eliminate some of its development programs or its future commercialization efforts, out-license intellectual property rights to its product candidates and sell unsecured assets, or a combination of the above, any of which may have a material adverse effect on the Company’s business, results of operations, financial condition and/or its ability to fund its scheduled obligations on a timely basis or at all. The Company believes that the existing capital resources will be sufficient to fund the projected operating requirements for at least twelve months after the filing date.

Balance Sheet Components - Components of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Balance Sheet Related Disclosures [Abstract]
Accrued contract manufacturing	$ 11,576	$ 5,249
Accrued clinical and nonclinical study costs	4,306	5,485
Accrued compensation and related expenses	4,005	3,708
Accrued property and equipment	176	2,110
Other	1,813	2,050
Total accrued expenses and other current liabilities	$ 21,876	$ 18,602

Leases - Supplemental Cash Flow Disclosures for Cash Paid for Leases (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases	$ 931	$ 681
Operating cash flows from finance leases	3	7
Financing cash flows from finance leases	325	281
Right-of-use asset acquired under leases
Operating leases		$ 4,684
Finance leases	$ 1,187

Related-Party Transactions

9 Months Ended

Sep. 30, 2023

RELATED-PARTY TRANSACTIONS

(9) RELATED-PARTY TRANSACTIONS

The Company has several related-party agreements with Tallac Therapeutics, Inc., or Tallac. The details of these agreements are described in our notes to our consolidated financial statements in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022, which was filed with the SEC on March 9, 2023. During the three months and nine months ended September 30, 2023, there were no material changes to these agreements.

Tallac Service Agreement

In each of the three months ended September 30, 2023 and 2022, the Company recorded $0.1 million and $0.2 million, respectively, as research and development, or R&D, costs in relation to the research and development services agreement with Tallac, or the Tallac Services Agreement. During the nine months ended September 30, 2023 and 2022, the Company recorded $0.3 million and $0.6 million, respectively, as R&D costs in relation to the Tallac Services Agreement.

Tallac Collaboration Agreement

During the three months ended September 30, 2023 and 2022, the Company recorded $0.3 million and $2.5 million, respectively, as R&D costs in relation to the collaboration agreement with Tallac, or the Tallac Collaboration Agreement. During the nine months ended September 30, 2023 and 2022, the Company recorded $1.2 million and $6.2 million, respectively, as R&D costs in relation to the Tallac Collaboration Agreement.

As of September 30, 2023 and December 31, 2022, the Company had accrued expenses of $0.3 million and $1.6 million, respectively, related to the Tallac Collaboration Agreement, which was presented within the payable and accrued liabilities due to related party on the condensed consolidated balance sheets.

- Definition

The entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.

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+ Details

Subsequent Events - Additional Information (Details) - Subsequent Event [Member] $ / shares in Units, $ in Millions	Oct. 10, 2023 USD ($) $ / shares shares
Over-Allotment Option \| Common Stock
Subsequent Event [Line Items]
Shares issued \| shares	1,293,103
Underwitten Follow-on Public Offering
Subsequent Event [Line Items]
Net proceeds received \| $	$ 59.0
Underwitten Follow-on Public Offering \| Common Stock
Subsequent Event [Line Items]
Shares issued \| shares	8,663,793
Offering price per share \| $ / shares	$ 6.38
Underwriting discounts and commissions paid \| $	$ 3.8
Payment for offering related expense \| $	$ 0.5
Underwitten Follow-on Public Offering \| Pre-funded Warrants
Subsequent Event [Line Items]
Warrants to purchase Shares of common stock \| shares	1,250,000
Offering price per share \| $ / shares	$ 6.379

Stock-Based Compensation - Additional Information (Details) - shares	Jan. 01, 2023	Sep. 30, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock reserved for future issuance		12,441,492
2020 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of additional shares reserved for future issuance	1,634,456

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Commitments and Contingencies (Tables)

9 Months Ended

Sep. 30, 2023

Commitments and Contingencies Disclosure [Abstract]

Summary of Other Contractual Obligations and Other Commitments from Manufacturing and Service Contracts

We have other contractual obligations and other commitments from manufacturing and service contracts, which are presented as follows as of September 30, 2023 (in thousands):


	September 30, 2023
	Total		2023 (remaining three months)		2024-2025		2026-2027		Thereafter
Manufacturing and service contracts	$	8,822	$	4,114	$	4,652	$	56	$	—
Total	$	8,822	$	4,114	$	4,652	$	56	$	—

Condensed Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Statement of Comprehensive Income [Abstract]
Net loss	$ (50,990)	$ (35,320)	$ (115,333)	$ (92,773)
Other comprehensive gain (loss), net of tax:
Unrealized gain (loss) on available-for-sale investments	86	(248)	619	(1,504)
Total comprehensive loss	$ (50,904)	$ (35,568)	$ (114,714)	$ (94,277)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

Net Loss Per Share - Computation of Basic and Diluted Net Loss per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2023	Jun. 30, 2023	Mar. 31, 2023	Sep. 30, 2022	Jun. 30, 2022	Mar. 31, 2022	Sep. 30, 2023	Sep. 30, 2022
Numerator:
Net loss	$ (50,990)	$ (34,159)	$ (30,184)	$ (35,320)	$ (32,920)	$ (24,533)	$ (115,333)	$ (92,773)
Denominator:
Weighted-average shares of common stock outstanding, basic	41,147,938			40,747,026			40,963,015	40,684,172
Weighted-average shares of common stock outstanding, diluted	41,147,938			40,747,026			40,963,015	40,684,172
Net loss per share, basic	$ (1.24)			$ (0.87)			$ (2.82)	$ (2.28)
Net loss per share, diluted	$ (1.24)			$ (0.87)			$ (2.82)	$ (2.28)

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

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The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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-URI https://asc.fasb.org//1943274/2147483589/942-220-S99-1

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 944
-SubTopic 220
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(23))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483586/944-220-S99-1

Reference 15: http://www.xbrl.org/2003/role/exampleRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 52
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482635/260-10-55-52

Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 7
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482689/260-10-45-7

+ Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 19,584	$ 48,822
Short-term investments	170,425	217,385
Prepaid expenses and other current assets	9,062	4,762
Total current assets	199,071	270,969
Property and equipment, net	3,617	3,889
Long-term investments	6,435	16,699
Other assets	10,984	14,932
Total assets	220,107	306,489
Current liabilities:
Accounts payable	13,001	8,073
Payable and accrued liabilities due to related party	$ 265	$ 1,650
Other Liability, Current, Related Party, Type [Extensible Enumeration]	us-gaap:RelatedPartyMember	us-gaap:RelatedPartyMember
Accrued expenses and other current liabilities	$ 21,876	$ 18,602
Total current liabilities	35,142	28,325
Term loan, non-current	9,575	9,389
Other non-current liabilities	6,638	5,311
Total liabilities	51,355	43,025
Commitments and contingencies (Note 11)
Stockholders’ equity
Common stock, $0.001 par value; 1,000,000,000 shares authorized as of September 30, 2023 and December 31, 2022; 41,151,819 and 40,861,386 shares issued and outstanding as of September 30, 2023 and December 31, 2022, respectively	41	41
Additional paid-in capital	609,737	589,735
Accumulated other comprehensive loss	(226)	(845)
Accumulated deficit	(440,800)	(325,467)
Total stockholders’ equity	168,752	263,464
Total liabilities and stockholders’ equity	$ 220,107	$ 306,489

Balance Sheet Components - Additional Information (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Balance Sheet Related Disclosures [Abstract]
Depreciation	$ 0.2	$ 0.1	$ 0.6	$ 0.2

Related-Party Transactions - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
Related Party Transaction [Line Items]
Research and development costs	$ 45,766	$ 29,382	$ 100,011	$ 73,203
Accrued expenses due	$ 265		$ 265		$ 1,650
Other Liability, Current, Related Party, Type [Extensible Enumeration]	us-gaap:RelatedPartyMember		us-gaap:RelatedPartyMember		us-gaap:RelatedPartyMember
Research and Development Services Agreement \| Tallac Therapeutics
Related Party Transaction [Line Items]
Research and development costs	$ 100	200	$ 300	600
Collaboration Agreement \| Tallac Therapeutics
Related Party Transaction [Line Items]
Research and development costs	300	$ 2,500	1,200	$ 6,200
Accrued expenses due	$ 300		$ 300		$ 1,600
Other Liability, Current, Related Party, Type [Extensible Enumeration]	us-gaap:RelatedPartyMember		us-gaap:RelatedPartyMember		us-gaap:RelatedPartyMember

Significant Accounting Policies

9 Months Ended

Sep. 30, 2023

Accounting Policies [Abstract]

SIGNIFICANT ACCOUNTING POLICIES

(2) SIGNIFICANT ACCOUNTING POLICIES

Basis of Preparation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States, or U.S. GAAP, and applicable rules and regulations of the Securities and Exchange Commission, or SEC, regarding interim financial reporting. Certain information and note disclosures normally included in the financial statements prepared in accordance with U.S. GAAP have been condensed or omitted pursuant to such rules and regulations. As such, the information included in this Quarterly Report on Form 10-Q should be read in conjunction with the consolidated financial statements and accompanying notes included in the Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on March 9, 2023.

The condensed consolidated balance sheet as of September 30, 2023 included herein was derived from the audited financial statements as of that date, but does not include all disclosures including notes required by U.S. GAAP.

The accompanying condensed consolidated financial statements reflect all normal recurring adjustments that are necessary to present fairly the results for the interim periods presented. Interim results are not necessarily indicative of the results for the full year ending December 31, 2023.

Reclassifications

Certain amounts in the prior period have been reclassified to conform to the current period presentation.

Principles of Consolidation

All intercompany balances and transactions have been eliminated in consolidation.

Use of Estimates

The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting periods. On an ongoing basis, management evaluates its estimates, including, but not limited to, those related to the estimated useful lives of long-lived assets, clinical trial accruals, fair value of assets and liabilities, fair value of investments and stock-based compensation. Management bases its estimates on historical experience and on various other market-specific and relevant assumptions that management believes to be reasonable under the circumstances. Actual results could differ from those estimates.

Significant Accounting Policies

There have been no new or material changes to the significant accounting policies discussed in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022.

Recent Accounting Pronouncements

None.

Net Loss Per Share - Summary of Outstanding Potentially Dilutive Securities Were Excluded from Computation of Diluted Net Loss Per Share (Details) - shares	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	10,199,289	7,106,281	10,199,289	7,106,281
Stock Options Issued and Outstanding
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	9,114,886	6,214,107	9,114,886	6,214,107
Restricted Stock Issued and Outstanding
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	1,084,403	870,399	1,084,403	870,399
Employee Stock Purchase Plan Estimated Shares Issuable
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share		21,775		21,775

Leases

9 Months Ended

Sep. 30, 2023

Leases [Abstract]

LEASES

(5) LEASES

The Company has non-cancelable operating leases for its offices located in the U.S. As of September 30, 2023, these leases expire on various dates between 2026 and 2030. Certain lease agreements include one or more options to renew, with renewal terms that can extend the lease up to two years after expiration. The Company has the right to exercise or forego the lease renewal options. The lease agreements do not contain any material residual value guarantees or material restrictive covenants.

The following table presents the maturities and balance sheet information of the Company’s operating lease liabilities as of September 30, 2023 (in thousands, except lease term and discount rate):


	September 30, 2023
	Operating Leases
2023	$	310
2024		1,267
2025		1,305
2026		1,187
2027		912
Thereafter		2,069
Total lease payments		7,050
Less: imputed interest		(1,596	)
Total lease liabilities	$	5,454

Lease liabilities: current (i)	$	823
Lease liabilities: non-current (ii)		4,631
Total lease liabilities	$	5,454

Weighted average remaining lease term (in years)		5.6
Weighted average discount rate		8.6	%

(i)

Current lease liabilities are presented within accrued expenses and other current liabilities on the condensed consolidated balance sheets.

(ii)

Non-current lease liabilities are presented within other non-current liabilities on the condensed consolidated balance sheets.

The following table presents the components of lease costs for the three months and nine months ended September 30, 2023 and 2022 (in thousands):


	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2023		2022		2023		2022
Operating lease cost	$	317	$	320	$	952	$	840
Variable lease cost and other, net (i)		128		60		347		203
Short-term lease cost		2		3		8		86
Finance lease cost:
Amortization of right-of-use assets		114		112		338		336
Interest		9		2		11		7
Total lease costs	$	570	$	497	$	1,656	$	1,472

(i)

The variable lease cost and other, net is comprised primarily of common area maintenance charges for the operating lease, which are dependent on usage. These costs are classified as operating lease expense due to the election to not separate lease and non-lease components. These costs were not included within the measurement of the Company’s operating lease ROU assets and operating lease liabilities.

The following table presents the supplemental cash flow disclosures for cash paid for leases for the nine months ended September 30, 2023 and 2022 (in thousands):


	Nine Months Ended
	September 30,
	2023		2022
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases	$	931	$	681
Operating cash flows from finance leases	$	3	$	7
Financing cash flows from finance leases	$	325	$	281
Right-of-use asset acquired under leases
Operating leases	$	—	$	4,684
Finance leases	$	1,187	$	—

Fair Value of Financial Instruments - Schedule of Available for Sale Investments Measured at Fair Value of Recurring Basis (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Debt Securities, Available-for-Sale [Line Items]
Fair Value	$ 195,963	$ 274,258
Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	196,189	275,103
Unrealized Gains	3	41
Unrealized Losses	(229)	(886)
Fair Value	195,963	274,258
Money Market Funds \| Level 1 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	19,103	36,690
Fair Value	19,103	36,690
U.S. Government Agency Securities \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost		3,484
Fair Value		3,484
Short Term Investment U.S. Treasury Securities \| Level 1 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	61,987	73,058
Unrealized Gains		3
Unrealized Losses	(96)	(438)
Fair Value	61,891	72,623
Short Term Investment U.S. Government Agency Securities \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	47,668	16,227
Unrealized Gains	2	36
Unrealized Losses	(110)
Fair Value	47,560	16,263
Short Term Investment Corporate Debt Securities \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	8,753	56,318
Unrealized Gains	1
Unrealized Losses	(14)	(367)
Fair Value	8,740	55,951
Short Term Investment Commercial Paper \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	51,474	62,087
Fair Value	51,474	62,087
Short Term Investment Asset-Backed Securities \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	764	10,512
Unrealized Losses	(4)	(51)
Fair Value	760	10,461
Long Term Investment Corporate Debt Securities \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	6,440
Unrealized Losses	(5)
Fair Value	$ 6,435
Long Term Investment U.S. Treasury Securities \| Level 1 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost		5,242
Unrealized Gains		2
Fair Value		5,244
Long-term Investment U.S. Government Agency Securities \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost		9,760
Unrealized Losses		(15)
Fair Value		9,745
Long Term Investment Asset-Backed Securities \| Level 2 \| Fair Value on Recurring Basis
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost		1,725
Unrealized Losses		(15)
Fair Value		$ 1,710

Term Loan - Schedule of Future Maturities Under the Loan Agreement (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Long-Term Debt, Fiscal Year Maturity [Abstract]
2025	$ 435
2026	5,217
2027	4,948
Total future maturities	10,600
Less: current portion of term loan	0
Total term loan, net of current portion	10,600
Less: unamortized debt issuance costs	(835)
Less: unaccreted final payment costs	(190)
Term loan, non-current, net	$ 9,575	$ 9,389

Commitments and Contingencies

9 Months Ended

Sep. 30, 2023

Commitments and Contingencies Disclosure [Abstract]

COMMITMENTS AND CONTINGENCIES

(11) COMMITMENTS AND CONTINGENCIES

Guarantees and Indemnifications

In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for general indemnifications. The Company’s exposure under these agreements is unknown because it involves claims that may be made against the Company in the future but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may record charges in the future as a result of these indemnification obligations. The Company also has indemnification obligations to its officers and directors for specified events or occurrences, subject to some limits, while they are serving at the Company’s request in such capacities. There have been no claims to date and the Company has director and officer insurance that may enable the Company to recover a portion of any amounts paid for future potential claims. The Company believes the fair value of these indemnification agreements is minimal. Accordingly, the Company has not recorded any liabilities for these agreements as of September 30, 2023.

Contingencies

From time to time, the Company may be a party to various claims in the normal course of business. Legal fees and other costs associated with such actions will be expensed as incurred. The Company will assess, in conjunction with its legal counsel, the need to record a liability for litigation and contingencies. Reserve estimates will be recorded when and if it is determined that a loss related matter is both probable and reasonably estimable. As of September 30, 2023, the Company had no pending or threatened litigation.

Other Contractual Obligations and Other Commitments

We have other contractual obligations and other commitments from manufacturing and service contracts, which are presented as follows as of September 30, 2023 (in thousands):


	September 30, 2023
	Total		2023 (remaining three months)		2024-2025		2026-2027		Thereafter
Manufacturing and service contracts	$	8,822	$	4,114	$	4,652	$	56	$	—
Total	$	8,822	$	4,114	$	4,652	$	56	$	—

In November 2015, the Company entered into a Master Service Agreement, or the MSA, with KBI Biopharma, Inc. relating to formulation development, process development and current good manufacturing practices, or cGMP, manufacturing of evorpacept for use in clinical trials on a project basis. The MSA had an initial term of three years with successive one-year renewal periods, which was extended an additional eight years until November 2026, is cancellable upon notice and is non-exclusive. Statements of work under the MSA commit the Company to certain future purchase obligations of approximately $2.6 million. In addition, the Company has commitments with one other pharmaceutical contract manufacturer, including certain future purchase obligations of approximately $6.2 million. These amounts are based on non-cancellable commitments and forecasts that include estimates of future market demand, quantity discounts and manufacturing efficiencies that may impact timing of purchases.

The Company enters into contracts in the normal course of business with various third parties for clinical trials, preclinical research studies and testing, manufacturing and other services and products for operating purposes. These contracts generally provide for termination upon notice. Payments due upon cancellation consist only of payments for services provided or expenses incurred, including non-cancellable obligations of the Company’s service providers, up to the date of cancellation.

Fair Value of Financial Instruments - Schedule of Fair Value of Available for Sale Investments (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total available-for-sale investments	$ 195,963	$ 274,258
Cash and Cash Equivalents
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash and cash equivalents available for sale	19,103	40,174
Short-term Investments
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short term investments available for sale	170,425	217,385
Long-term Investments
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Long term investments available for sale	$ 6,435	$ 16,699

Net Loss Per Share (Tables)

9 Months Ended

Sep. 30, 2023

Earnings Per Share [Abstract]

Computation of Basic and Diluted Net Loss per Share


	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2023			2022			2023			2022
Numerator:
Net loss	$	(50,990	)	$	(35,320	)	$	(115,333	)	$	(92,773	)
Denominator:
Weighted-average shares of common stock outstanding, basic and diluted		41,147,938			40,747,026			40,963,015			40,684,172
Net loss per share, basic and diluted	$	(1.24	)	$	(0.87	)	$	(2.82	)	$	(2.28	)

Summary of Outstanding Potentially Dilutive Securities Were Excluded from Computation of Diluted Net Loss Per Share


	Three and Nine Months Ended
	September 30,
	2023		2022
Stock options issued and outstanding		9,114,886		6,214,107
Restricted stock issued and outstanding		1,084,403		870,399
Employee Stock Purchase Plan estimated shares issuable		—		21,775
Total		10,199,289		7,106,281

Balance Sheet Components - Schedule of Components of Property and Equipment (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 4,649	$ 4,292
Less: accumulated depreciation	(1,032)	(403)
Property and equipment, net	3,617	3,889
Leasehold Improvements
Property Plant And Equipment [Line Items]
Property and equipment, gross	2,513	2,360
Laboratory Equipment
Property Plant And Equipment [Line Items]
Property and equipment, gross	1,570	1,422
Computer Hardware and Software
Property Plant And Equipment [Line Items]
Property and equipment, gross	400	344
Furniture and Fixtures
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 166	$ 166

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Sep. 30, 2023	Dec. 31, 2022
Statement of Financial Position [Abstract]
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	1,000,000,000	1,000,000,000
Common stock, shares issued	41,151,819	40,861,386
Common stock, shares outstanding	41,151,819	40,861,386

Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2023

Equity [Abstract]

Common Stock Reserved for Future Issuance

Common stock reserved for future issuance as of September 30, 2023 consists of the following:


	September 30, 2023
Stock options issued and outstanding		9,114,886
Stock options authorized for future issuance		1,147,137
Employee Stock Purchase Plan shares authorized for future issuance		1,095,066
Restricted stock issued and outstanding		1,084,403
Total		12,441,492

Balance Sheet Components - Schedule of Components of Other Assets, Net (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Property Plant And Equipment [Line Items]
Operating lease right-of-use assets	$ 5,044	$ 5,626
Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]	Total other assets	Total other assets
Other	$ 210	$ 288
Finance lease right-of-use assets	$ 1,147	$ 298
Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]	Total other assets	Total other assets
Total other assets	$ 10,984	$ 14,932
Long-term Prepaid Clinical Expenses
Property Plant And Equipment [Line Items]
Long-term prepaid expenses	4,311	7,264
Long-term Prepaid Contract Manufacturing Costs
Property Plant And Equipment [Line Items]
Long-term prepaid expenses	$ 272	$ 1,456

Fair Value of Financial Instruments (Tables)

9 Months Ended

Sep. 30, 2023

Fair Value Disclosures [Abstract]

Financial Assets Measured at Fair Value on Recurring Basis

The following table presents the Company’s investments, which consist of cash equivalents and investments classified as available-for-sale investments, that are measured at fair value on a recurring basis by level within the fair value hierarchy as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30, 2023
	Fair Value Hierarchy Level	Amortized Cost		Unrealized Gains		Unrealized Losses			Fair Value
Cash equivalents
Money market funds	Level 1	$	19,103	$	—	$	—		$	19,103
Short-term investments
U.S. Treasury securities	Level 1		61,987		—		(96	)		61,891
U.S. government agency securities	Level 2		47,668		2		(110	)		47,560
Corporate debt securities	Level 2		8,753		1		(14	)		8,740
Commercial paper	Level 2		51,474		—		—			51,474
Asset-backed securities	Level 2		764		—		(4	)		760
Long-term investments
Corporate debt securities	Level 2		6,440		—		(5	)		6,435
Total		$	196,189	$	3	$	(229	)	$	195,963


	December 31, 2022
	Fair Value Hierarchy Level	Amortized Cost		Unrealized Gains		Unrealized Losses			Fair Value
Cash equivalents
Money market funds	Level 1	$	36,690	$	—	$	—		$	36,690
U.S. government agency securities	Level 2		3,484		—		—			3,484
Short-term investments
U.S. Treasury securities	Level 1		73,058		3		(438	)		72,623
U.S. government agency securities	Level 2		16,227		36		—			16,263
Corporate debt securities	Level 2		56,318		—		(367	)		55,951
Commercial paper	Level 2		62,087		—		—			62,087
Asset-backed securities	Level 2		10,512		—		(51	)		10,461
Long-term investments
U.S. Treasury securities	Level 1		5,242		2		—			5,244
U.S. government agency securities	Level 2		9,760		—		(15	)		9,745
Asset-backed securities	Level 2		1,725		—		(15	)		1,710
Total		$	275,103	$	41	$	(886	)	$	274,258

Schedule of Fair Value of Available for Sale Investments

The fair value of cash equivalents and available-for-sale investments by classification included in the condensed consolidated balance sheets was as follows as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,		December 31,
	2023		2022
Cash and cash equivalents	$	19,103	$	40,174
Short-term investments		170,425		217,385
Long-term investments		6,435		16,699
Total	$	195,963	$	274,258

Schedule of Fair Value of Available-for-Sale Investments by Contractual Maturity

The fair value of cash equivalents and available-for-sale investments by contractual maturity was as follows as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,		December 31,
	2023		2022
Maturing in one year or less	$	189,528	$	257,559
Maturing after one year through five years		6,435		16,699
Total	$	195,963	$	274,258

Stockholders' Equity - Additional Information (Details) - $ / shares	Sep. 30, 2023	Dec. 31, 2022	Jul. 21, 2020
Class Of Stock [Line Items]
Common stock, shares authorized	1,000,000,000	1,000,000,000	1,000,000,000
Common stock, par value	$ 0.001	$ 0.001	$ 0.001
Preferred stock, par value			$ 0.001
Common stock, shares outstanding	41,151,819	40,861,386
Undesignated Preferred Stock
Class Of Stock [Line Items]
Preferred stock, shares authorized			100,000,000

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 2: http://www.xbrl.org/2003/role/recommendedDisclosureRef
-Topic 272
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483014/272-10-45-3

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 272
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482987/272-10-50-1

Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(d))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (e)
-Publisher FASB
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-14

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 18
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 210
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(27)(b))
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 210
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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-Topic 946
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479886/946-10-S99-3

+ Details

Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2023

Share-Based Payment Arrangement [Abstract]

Summary of Share-Based Compensation Expense

Total stock-based compensation expense recognized in the condensed consolidated statements of operations was as follows (in thousands):


	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2023		2022		2023		2022
Research and development	$	3,728	$	2,931	$	10,011	$	7,696
General and administrative		3,236		3,276		9,541		9,848
Total	$	6,964	$	6,207	$	19,552	$	17,544

Stock-Based Compensation

9 Months Ended

Sep. 30, 2023

Share-Based Payment Arrangement [Abstract]

STOCK-BASED COMPENSATION

(8) STOCK-BASED COMPENSATION

Amended and Restated 2020 Equity Incentive Plan

The Company’s Amended and Restated 2020 Equity Incentive Plan, or the 2020 Plan, serves as the successor to the Company’s 2020 Equity Incentive Plan and provides for the granting of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock, restricted stock units, performance units and performance shares.

On January 1, 2023, the number of shares available under the 2020 Plan was increased by 1,634,456 shares.

Employee Stock Purchase Plan

Under the Company’s 2020 Employee Stock Purchase Plan, or the ESPP, eligible employees are entitled to purchase shares of common stock with accumulated payroll deductions.

Stock-based Compensation Expenses

Total stock-based compensation expense recognized in the condensed consolidated statements of operations was as follows (in thousands):


	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2023		2022		2023		2022
Research and development	$	3,728	$	2,931	$	10,011	$	7,696
General and administrative		3,236		3,276		9,541		9,848
Total	$	6,964	$	6,207	$	19,552	$	17,544

Significant Accounting Policies (Policies)	9 Months Ended
Significant Accounting Policies (Policies)	Sep. 30, 2023
Accounting Policies [Abstract]
Basis of Presentation	Basis of Preparation The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States, or U.S. GAAP, and applicable rules and regulations of the Securities and Exchange Commission, or SEC, regarding interim financial reporting. Certain information and note disclosures normally included in the financial statements prepared in accordance with U.S. GAAP have been condensed or omitted pursuant to such rules and regulations. As such, the information included in this Quarterly Report on Form 10-Q should be read in conjunction with the consolidated financial statements and accompanying notes included in the Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on March 9, 2023. The condensed consolidated balance sheet as of September 30, 2023 included herein was derived from the audited financial statements as of that date, but does not include all disclosures including notes required by U.S. GAAP. The accompanying condensed consolidated financial statements reflect all normal recurring adjustments that are necessary to present fairly the results for the interim periods presented. Interim results are not necessarily indicative of the results for the full year ending December 31, 2023.
Reclassifications	Reclassifications Certain amounts in the prior period have been reclassified to conform to the current period presentation.
Principles of Consolidation	Principles of Consolidation All intercompany balances and transactions have been eliminated in consolidation.
Use of Estimates	Use of Estimates The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting periods. On an ongoing basis, management evaluates its estimates, including, but not limited to, those related to the estimated useful lives of long-lived assets, clinical trial accruals, fair value of assets and liabilities, fair value of investments and stock-based compensation. Management bases its estimates on historical experience and on various other market-specific and relevant assumptions that management believes to be reasonable under the circumstances. Actual results could differ from those estimates.
Adopted Accounting Pronouncements	Accounting Pronouncements None.

Stockholders' Equity - Common Stock Reserved for Future Issuance (Details)	Sep. 30, 2023 shares
Class Of Stock [Line Items]
Common stock reserved for future issuance	12,441,492
Stock Options Issued and Outstanding
Class Of Stock [Line Items]
Common stock reserved for future issuance	9,114,886
Stock Options Authorized for Future Issuance
Class Of Stock [Line Items]
Common stock reserved for future issuance	1,147,137
Employee Stock Purchase Plan Shares Authorized for Future Issuance
Class Of Stock [Line Items]
Common stock reserved for future issuance	1,095,066
Restricted Stock Issued and Outstanding
Class Of Stock [Line Items]
Common stock reserved for future issuance	1,084,403

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Fair Value of Financial Instruments

9 Months Ended

Sep. 30, 2023

Fair Value Disclosures [Abstract]

FAIR VALUE OF FINANCIAL INSTRUMENTS

(3) FAIR VALUE OF FINANCIAL INSTRUMENTS

The fair value of the Company’s financial assets and liabilities are determined in accordance with the fair value hierarchy established in ASC 820, Fair Value Measurements and Disclosures.


	September 30, 2023
	Fair Value Hierarchy Level	Amortized Cost		Unrealized Gains		Unrealized Losses			Fair Value
Cash equivalents
Money market funds	Level 1	$	19,103	$	—	$	—		$	19,103
Short-term investments
U.S. Treasury securities	Level 1		61,987		—		(96	)		61,891
U.S. government agency securities	Level 2		47,668		2		(110	)		47,560
Corporate debt securities	Level 2		8,753		1		(14	)		8,740
Commercial paper	Level 2		51,474		—		—			51,474
Asset-backed securities	Level 2		764		—		(4	)		760
Long-term investments
Corporate debt securities	Level 2		6,440		—		(5	)		6,435
Total		$	196,189	$	3	$	(229	)	$	195,963


	December 31, 2022
	Fair Value Hierarchy Level	Amortized Cost		Unrealized Gains		Unrealized Losses			Fair Value
Cash equivalents
Money market funds	Level 1	$	36,690	$	—	$	—		$	36,690
U.S. government agency securities	Level 2		3,484		—		—			3,484
Short-term investments
U.S. Treasury securities	Level 1		73,058		3		(438	)		72,623
U.S. government agency securities	Level 2		16,227		36		—			16,263
Corporate debt securities	Level 2		56,318		—		(367	)		55,951
Commercial paper	Level 2		62,087		—		—			62,087
Asset-backed securities	Level 2		10,512		—		(51	)		10,461
Long-term investments
U.S. Treasury securities	Level 1		5,242		2		—			5,244
U.S. government agency securities	Level 2		9,760		—		(15	)		9,745
Asset-backed securities	Level 2		1,725		—		(15	)		1,710
Total		$	275,103	$	41	$	(886	)	$	274,258


	September 30,		December 31,
	2023		2022
Cash and cash equivalents	$	19,103	$	40,174
Short-term investments		170,425		217,385
Long-term investments		6,435		16,699
Total	$	195,963	$	274,258

Cash and cash equivalents in the above table excludes bank account cash of $0.5 million and $8.6 million as of September 30, 2023 and December 31, 2022, respectively.

The fair value of cash equivalents and available-for-sale investments by contractual maturity was as follows as of September 30, 2023 and December 31, 2022 (in thousands):


	September 30,		December 31,
	2023		2022
Maturing in one year or less	$	189,528	$	257,559
Maturing after one year through five years		6,435		16,699
Total	$	195,963	$	274,258

There were no transfers of financial instruments between the fair value measurement levels during the three months and nine months ended September 30, 2023 and 2022 and there were no financial instruments classified as Level 3 as of September 30, 2023 and 2022.

As of September 30, 2023 and December 31, 2022, accrued interest receivable related to the Company’s investments of $0.6 million and $1.0 million, respectively, was included in prepaid expenses and other current assets on the condensed consolidated balance sheet.

As of September 30, 2023, the unrealized losses for available-for-sale investments were non-credit related and the Company does not intend to sell the investments that were in an unrealized loss position, nor does it foresee or project that it will be required to sell those investments before recovery of their amortized costs basis, which may be maturity. As of September 30, 2023, no allowance for credit losses for the Company’s investments was recorded. As of September 30, 2023 and December 31, 2022, securities with a fair value of $2.3 million and zero, respectively, were in a continuous net unrealized loss position for more than 12 months. As of September 30, 2023, the Company has not recognized any impairment losses on available-for-sale investments.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Leases - Schedule of Maturities of Operating and Finance Lease Liabilities (Details) $ in Thousands	Sep. 30, 2023 USD ($)
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
2023	$ 310
2024	1,267
2025	1,305
2026	1,187
2027	912
Thereafter	2,069
Total lease payments	7,050
Less: imputed interest	(1,596)
Operating lease liabilities	5,454
Lease liabilities: current	$ 823
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Accrued Liabilities and Other Liabilities
Lease liabilities: non-current	$ 4,631
Operating lease, liability, noncurrent, statement of financial position [extensible list]	Other non-current liabilities
Total lease liabilities	$ 5,454
Weighted average remaining lease term (in years)	5 years 7 months 6 days
Weighted average discount rate	8.60%

Document and Entity Information - shares	9 Months Ended
Document and Entity Information - shares	Sep. 30, 2023	Nov. 06, 2023
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Sep. 30, 2023
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q3
Current Fiscal Year End Date	--12-31
Entity Registrant Name	ALX ONCOLOGY HOLDINGS INC
Entity Central Index Key	0001810182
Entity File Number	001-39386
Entity Tax Identification Number	85-0642577
Entity Incorporation, State or Country Code	DE
Entity Address, Address Line One	323 Allerton Avenue
Entity Address, City or Town	South San Francisco
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94080
City Area Code	650
Local Phone Number	466-7125
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Common Stock, Shares Outstanding		49,818,812
Entity Shell Company	false
Title of 12(b) Security	Common Stock, par value $0.001 per share
Trading Symbol	ALXO
Security Exchange Name	NASDAQ
Document Quarterly Report	true
Document Transition Report	false

Fair Value of Financial Instruments - Additional Information (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair value assets and liabilities transfers amount	$ 0	$ 0	$ 0	$ 0
Fair value assets transferred into level 3			0	0
Fair value assets transferred out of level 3			0	0
Fair value liabilities transferred into level 3			0	0
Fair value liabilities transferred out of level 3			0	$ 0
Accrued interest receivable, investment	$ 600,000		$ 600,000		$ 1,000,000
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Statement of Financial Position [Extensible Enumeration]	Prepaid Expense and Other Assets, Current		Prepaid Expense and Other Assets, Current		Prepaid Expense and Other Assets, Current
Bank account cash	$ 500,000		$ 500,000		$ 8,600,000
Allowance for credit losses	0		0
Fair value of securities, continuous unrealized loss position for more than 12 months	$ 2,300,000		2,300,000		$ 0
Impairment losses on available-for-sale investments			$ 0

Leases - Components of Lease Costs (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Leases [Abstract]
Operating lease cost	$ 317	$ 320	$ 952	$ 840
Variable lease cost and other, net	128	60	347	203
Short-term lease cost	2	3	8	86
Finance lease cost, Amortization of right-of-use assets	114	112	338	336
Finance lease cost, Interest	9	2	11	7
Total lease costs	$ 570	$ 497	$ 1,656	$ 1,472

Subsequent Events

9 Months Ended

Sep. 30, 2023

Subsequent Events [Abstract]

SUBSEQUENT EVENTS

(12) SUBSEQUENT EVENTS

On October 10, 2023, the Company completed an underwitten follow-on public offering and issued an aggregate of 8,663,793 shares of common stock, including the underwriters’ exercise in full of their overallotment option of 1,293,103 shares of common stock, and pre-funded warrants to purchase 1,250,000 shares of common stock at a public offering price of $6.38 per share and $6.379 per pre-funded warrant. The Company received net proceeds of approximately $59.0 million, after deducting underwriting discounts and commissions of $3.8 million and other offering-related expenses of $0.5 million.

Leases (Tables)

9 Months Ended

Sep. 30, 2023

Leases [Abstract]

Schedule of Maturities of Operating and Finance Lease Liabilities

The following table presents the maturities and balance sheet information of the Company’s operating lease liabilities as of September 30, 2023 (in thousands, except lease term and discount rate):


	September 30, 2023
	Operating Leases
2023	$	310
2024		1,267
2025		1,305
2026		1,187
2027		912
Thereafter		2,069
Total lease payments		7,050
Less: imputed interest		(1,596	)
Total lease liabilities	$	5,454

Lease liabilities: current (i)	$	823
Lease liabilities: non-current (ii)		4,631
Total lease liabilities	$	5,454

Weighted average remaining lease term (in years)		5.6
Weighted average discount rate		8.6	%

(i)

Current lease liabilities are presented within accrued expenses and other current liabilities on the condensed consolidated balance sheets.

(ii)

Non-current lease liabilities are presented within other non-current liabilities on the condensed consolidated balance sheets.

Components of Lease Costs

The following table presents the components of lease costs for the three months and nine months ended September 30, 2023 and 2022 (in thousands):


	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2023		2022		2023		2022
Operating lease cost	$	317	$	320	$	952	$	840
Variable lease cost and other, net (i)		128		60		347		203
Short-term lease cost		2		3		8		86
Finance lease cost:
Amortization of right-of-use assets		114		112		338		336
Interest		9		2		11		7
Total lease costs	$	570	$	497	$	1,656	$	1,472

(i)

Supplemental Cash Flow Disclosures for Cash Paid for Leases

The following table presents the supplemental cash flow disclosures for cash paid for leases for the nine months ended September 30, 2023 and 2022 (in thousands):


	Nine Months Ended
	September 30,
	2023		2022
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases	$	931	$	681
Operating cash flows from finance leases	$	3	$	7
Financing cash flows from finance leases	$	325	$	281
Right-of-use asset acquired under leases
Operating leases	$	—	$	4,684
Finance leases	$	1,187	$	—

Term Loan - Additional Information (Details)		1 Months Ended		3 Months Ended		9 Months Ended
Term Loan - Additional Information (Details)	Mar. 10, 2023	May 31, 2023	Oct. 31, 2022 USD ($)	Sep. 30, 2023 USD ($) Lenders	Sep. 30, 2022 USD ($)	Sep. 30, 2023 USD ($) Lenders	Sep. 30, 2022 USD ($)
Oxford-SVB Loan Agreement
Debt Instrument [Line Items]
Issuance of term loan			$ 9,300,000
Draw an additional loan			50,000,000
deduction of debt issuance costs			700,000
Interest expense				$ 300,000		$ 800,000
Number of lenders \| Lenders				3		3
SVB
Debt Instrument [Line Items]
Loan Agreement with Lenders	50.00%
Term Loan \| Oxford-SVB Loan Agreement
Debt Instrument [Line Items]
Interest expense					$ 0		$ 0
Outstanding debt					$ 0		$ 0
Tranche A \| Oxford-SVB Loan Agreement
Debt Instrument [Line Items]
Issuance of term loan			10,000,000
Draw an additional loan			40,000,000
Tranche B \| Oxford-SVB Loan Agreement
Debt Instrument [Line Items]
Available borrowing capacity upon achievement of milestones			12,500,000
Tranche C \| Oxford-SVB Loan Agreement
Debt Instrument [Line Items]
Available borrowing capacity upon achievement of milestones			12,500,000
Tranche D \| Oxford-SVB Loan Agreement
Debt Instrument [Line Items]
Available borrowing capacity at lender's discretion			25,000,000
Maximum \| SVB
Debt Instrument [Line Items]
Percentage of loan agreement amount to be held in collateral account.		100.00%
Maximum \| Secured Term Loan Facility \| Oxford-SVB Loan Agreement
Debt Instrument [Line Items]
Term loan, principal amount			$ 100,000,000
Minimum \| SVB
Debt Instrument [Line Items]
Percentage of loan agreement amount to be held in collateral account.		50.00%

Commitments and Contingencies - Additional Information (Details)	1 Months Ended
	Nov. 30, 2015 USD ($)	Sep. 30, 2023 USD ($) Litigation
Commitments And Contingencies [Line Items]
Guarantee obligations		$ 8,822,000
Future purchase obligations		$ 8,822,000
Number of pending or threatened litigation \| Litigation		0
Master Service Agreement
Commitments And Contingencies [Line Items]
Initial term of agreement	3 years
Renewal periods of agreement	1 year
Future purchase obligations	$ 2,600,000
Other Pharmaceutical Manufacturing Contract
Commitments And Contingencies [Line Items]
Future purchase obligations		$ 6,200,000
Indemnification Agreement
Commitments And Contingencies [Line Items]
Guarantee obligations		$ 0

Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Operating expenses:
Research and development	$ 45,766	$ 29,382	$ 100,011	$ 73,203
General and administrative	7,509	7,299	22,244	22,014
Total operating expenses	53,275	36,681	122,255	95,217
Loss from operations	(53,275)	(36,681)	(122,255)	(95,217)
Interest income	2,677	1,370	7,654	2,471
Interest expense	(391)	(2)	(1,150)	(7)
Other income (expense), net	(1)	(7)	418	(20)
Net loss	$ (50,990)	$ (35,320)	$ (115,333)	$ (92,773)
Net loss per share, basic	$ (1.24)	$ (0.87)	$ (2.82)	$ (2.28)
Net loss per share, diluted	$ (1.24)	$ (0.87)	$ (2.82)	$ (2.28)
Weighted-average shares of common stock used to compute net loss per share, basic	41,147,938	40,747,026	40,963,015	40,684,172
Weighted-average shares of common stock used to compute net loss per share, diluted	41,147,938	40,747,026	40,963,015	40,684,172