75000 - Document - Document and Entity Information
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75010 - Statement - Consolidated Balance Sheets
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75020 - Statement - Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Consolidated Statements of Operations
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75040 - Statement - Consolidated Statements of Comprehensive Loss
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75050 - Statement - Consolidated Statements of Stockholders' Equity
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75060 - Statement - Consolidated Statements of Stockholders' Equity (Parenthetical)
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75070 - Statement - Consolidated Statements of Cash Flows
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75080 - Statement - Consolidated Statements of Cash Flows 2
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75090 - Statement - Consolidated Statements of Cash Flows (Parenthetical)
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995455 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995465 - Disclosure - Organization
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995475 - Disclosure - Significant Accounting Policies
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995485 - Disclosure - Segment Reporting
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995495 - Disclosure - Fair Value of Financial Instruments
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995505 - Disclosure - Balance Sheet Components
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995515 - Disclosure - Leases
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995525 - Disclosure - Term Loan
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995535 - Disclosure - Stockholders' Equity
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995545 - Disclosure - Stock-Based Compensation
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995555 - Disclosure - Related-Party Transactions
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995565 - Disclosure - Income Taxes
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995575 - Disclosure - Net Loss Per Share Attributable to Common Stockholders
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995585 - Disclosure - Commitments and Contingencies
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995595 - Disclosure - Subsequent Events
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995605 - Disclosure - Significant Accounting Policies (Policies)
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995615 - Disclosure - Segment Reporting (Tables)
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995625 - Disclosure - Fair Value of Financial Instruments (Tables)
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995635 - Disclosure - Balance Sheet Components (Tables)
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995645 - Disclosure - Leases (Tables)
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995655 - Disclosure - Term Loan (Tables)
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995665 - Disclosure - Stockholders' Equity (Tables)
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995675 - Disclosure - Stock-Based Compensation (Tables)
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995685 - Disclosure - Income Taxes (Tables)
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995695 - Disclosure - Net Loss Per Share Attributable to Common Stockholders (Tables)
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995705 - Disclosure - Commitments and Contingencies (Tables)
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995715 - Disclosure - Significant Accounting Policies - Additional Information (Details)
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995725 - Disclosure - Segment Reporting - Additional Information (Details)
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995735 - Disclosure - Segment Reporting - Summary of Disaggregated Segment Expenses Split between R&D and G&A Costs (Details)
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995745 - Disclosure - Fair Value of Financial Instruments - Financial Assets Measured at Fair Value on Recurring Basis (Details)
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995755 - Disclosure - Fair Value of Financial Instruments - Additional Information (Details)
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995765 - Disclosure - Fair Value of Financial Instruments - Schedule of Fair Value of Available for Sale Investments (Details)
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995775 - Disclosure - Fair Value of Financial Instruments - Schedule of Fair Value of Available-for-sale Investments by Contractual Maturity (Details)
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995785 - Disclosure - Balance Sheet Components - Schedule of Components of Prepaid Expenses and Other Current Assets (Details)
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995795 - Disclosure - Balance Sheet Components - Schedule of Components of Property and Equipment (Details)
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995805 - Disclosure - Balance Sheet Components - Additional Information (Details)
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995815 - Disclosure - Balance Sheet Components - Schedule of Components of Other Assets, Net (Details)
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995825 - Disclosure - Balance Sheet Components - Components of Accrued Expenses and Other Current Liabilities (Details)
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995835 - Disclosure - Leases - Additional Information (Details)
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995845 - Disclosure - Leases - Schedule of Maturities of Operating and Finance Lease Liabilities (Details)
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995855 - Disclosure - Leases - Schedule of Maturities of Operating and Finance Lease Liabilities (Details) 2
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995865 - Disclosure - Leases - Components of Lease Costs (Details)
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995875 - Disclosure - Leases - Supplemental Cash Flow Disclosures for Cash Paid for Leases (Details)
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995885 - Disclosure - Term Loan - Additional Information (Details)
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995895 - Disclosure - Term Loan - Schedule of Future Maturities Under the Loan Agreement (Details)
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995905 - Disclosure - Term Loan - Schedule of Future Maturities Under the Loan Agreement (Details) 2
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995915 - Disclosure - Term Loan - Schedule of Future Maturities Under the Loan Agreement (Details) 3
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995925 - Disclosure - Stockholders' Equity - Additional Information (Details)
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995935 - Disclosure - Stockholders' Equity - Common Stock Reserved for Future Issuance (Details)
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995945 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995955 - Disclosure - Stock-Based Compensation - Summary of Shares Available for Grant (Details)
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995965 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Details)
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995975 - Disclosure - Stock-Based Compensation - Schedule of Fair Value of Each Option Grant Using Black-Scholes Option-Pricing Model (Details)
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995985 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Unit (RSU) Activity (Details)
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995995 - Disclosure - Stock-Based Compensation - Summary of Share-Based Compensation Expense (Details)
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996005 - Disclosure - Related-Party Transactions - Additional Information (Details)
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996015 - Disclosure - Income Taxes - Domestic and International Components of Pre-Tax Loss (Details)
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996025 - Disclosure - Income Taxes - Schedule of Provision (Benefit) for Income Taxes (Details)
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996035 - Disclosure - Income Taxes - Schedule of Provision (Benefit) for Income Taxes (Details) 2
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996045 - Disclosure - Income Taxes - Schedule of Statutory and Effective Income Tax Rate Reconciliation (Details)
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996055 - Disclosure - Income Taxes - Significant Components of Deferred Tax Assets (Details)
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996065 - Disclosure - Income Taxes - Additional Information (Details)
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996075 - Disclosure - Income Taxes - Schedule of Reconciliation of Total Change in Valuation Allowance (Details)
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996085 - Disclosure - Income Taxes - Schedule of Net Operating Losses and Tax Credit Carryforwards (Details)
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996095 - Disclosure - Income Taxes - Schedule of Unrecognized Tax Benefits (Details)
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996105 - Disclosure - Net Loss Per Share Attributable to Common Stockholders - Computation of Basic and Diluted Net Loss per Share (Details)
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996115 - Disclosure - Net Loss Per Share Attributable to Common Stockholders - Summary of Outstanding Potentially Dilutive Securities Were Excluded from Computation of Diluted Net Loss Per Share (Details)
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996125 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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996135 - Disclosure - Commitments and Contingencies - Summary of Other Contractual Obligations and Other Commitments from Manufacturing and Service Contracts (Details)
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996145 - Disclosure - Subsequent Events - Additional Information (Details)
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Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted-Average Grant Date Fair Value, Vested
Income (Loss) from Continuing Operations before Income Taxes, Foreign
International
Series A Convertible Preferred Stock
Series A Convertible Preferred Stock [Member]
Series A convertible preferred stock.
Long-term Prepaid Clinical Expenses
Prepaid Clinical Expenses [Member]
Prepaid clinical expenses.
Lessee, Operating Lease, Liability, to be Paid, Rolling Year Three
2028
Total lease liabilities
Finance lease liabilities
Finance Lease, Liability
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Statement of Financial Position [Extensible Enumeration]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Balance Sheet Location
Statement of Financial Position Location, Balance [Domain]
Lessee operating lease expiration date.
Lessee Operating Lease Expiration Date
Lessee operating lease expiration date
Prepaid Clinical Expenses
Prepaid clinical expenses.
Prepaid clinical expenses
Cash paid for amounts included in the measurement of lease liabilities.
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Cash paid for amounts included in the measurement of lease liabilities:
Cash paid for amounts included in the measurement of lease liabilities:
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Supplemental disclosure of non-cash investing and financing activities
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Maturing in one year or less
Long-Term Debt, Excluding Current Maturities
Term loan, non-current, net
Total term loan, net of current portion
Term loan, non-current, net
Plan Name
Plan Name [Axis]
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Fair value of securities, continuous unrealized loss position for more than 12 months
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
US Government Agencies Debt Securities [Member]
U.S. Government Agency Securities
Tranche B [Member]
Tranche B
Tranche B.
Recently Issued Accounting Pronouncements Not Yet Adopted [Policy Text Block]
Recently issued accounting pronouncements not yet adopted.
Recently Issued Accounting Pronouncements Not Yet Adopted
Operating expenses:
Operating Expenses [Abstract]
Level 2
Fair Value, Inputs, Level 2 [Member]
Total deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
COMMITMENTS AND CONTINGENCIES
Commitments and Contingencies Disclosure [Text Block]
Common stock, shares authorized
Common Stock, Shares Authorized
Agreement automatically renewal additional term unless terminated
Related Party Agreement Automatically Renewal Additional Term Unless Terminated
Related party agreement automatically renewal additional term unless terminated.
Investment, Policy [Policy Text Block]
Investments
Document Fiscal Period Focus
Document Fiscal Period Focus
Operating lease, right-of-use asset, statement of financial position [extensible list]
Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]
Total lease payments
Finance Lease, Liability, to be Paid
Deferred tax assets capitalized research and development.
Deferred Tax Assets Capitalized Research And Development
Capitalized R&D
ASU No. 2023-09
Accounting Standards Update 2023-09 [Member]
Clinical and contract manufacturing accruals.
Clinical and Contract Manufacturing Accruals [Policy Text Block]
Clinical and Contract Manufacturing Accruals
Entity Shell Company
Entity Shell Company
Lessee, Operating Lease, Liability, to be Paid, Rolling Year Four
2029
Contractual Obligation, Total
Contractual Obligation
Guarantee obligations
Other Accrued Liabilities, Current
Other current liabilities
Short-Term Investments [Member]
Short-term Investments
Segment Reporting
Segment Reporting, Policy [Policy Text Block]
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalent
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued, Total
Common stock, shares issued
Common Stock, Shares, Issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Operating lease, description
Lessee, Operating Lease, Description
Asset Class [Domain]
Clinical and regulatory milestones payments
Clinical And Regulatory Milestones Payments
Clinical and regulatory milestones payments.
Statement [Table]
Statement [Table]
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increases related to current year tax positions
Operating leases
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use asset acquired under operating leases
Annual base rent
Operating Lease Annual Lease Expense
Operating lease annual lease expense.
Weighted-average grant-date fair value per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Statement [Line Items]
Statement [Line Items]
2020 Plan
Amended And Restated Two Thousand Twenty Equity Incentive Plan [Member]
Amended and restated 2020 equity incentive plan.
Entity Filer Category
Entity Filer Category
Commission Costs
Commission costs.
Commissions
Proceeds From Equity Offerings, Net Of Underwriter Discounts And Issuance Costs
Proceeds from equity offerings, net of underwriter discounts and issuance costs.
Proceeds from equity offerings, net of underwriter discounts ($3,795 thousand) and issuance costs ($567 thousand)
Cash equivalents available for sale.
Cash Equivalents Available for Sale
Cash and cash equivalents available for sale
Cash equivalents available for sale
Performance Based Restricted Stock Unit [Member]
Performance based restricted stock unit.
Performance-Based Restricted Stock Units
Total liabilities and stockholders’ equity
Liabilities and Equity
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Long-Term Debt, Current Maturities, Total
Long-Term Debt, Current Maturities
Term loan, current
Less: current portion of term loan
Long-Term Debt, Maturity, Year Three
2028
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercisable at December 31, 2025
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Operating Lease Right Of Use Asset And Leasehold Improvements Net Book Value
Operating lease right of use asset and leasehold improvements net book value.
Operating lease right of use asset and leasehold improvements net book value
Deferred tax assets, increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Prepaid Expenses and Other Current Assets
Prepaid Expenses and Other Current Assets [Member]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Additions/reversals based on tax positions of prior years
Unrecognized Tax Benefits Increases Decreases Resulting From Prior Period Tax Positions
Unrecognized tax benefits increases (decreases) resulting from prior period tax positions.
Issuance of term loan
Drew an initial loan
Principal payments on term loan
Deferred Tax Assets, Valuation Allowance, Total
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Ending balance
Beginning balance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
At federal statutory income tax rate
Shares original issue price
Shares Issued, Price Per Share
Subsequent Event [Line Items]
RestructuringAndRelatedCostNumberOfPositionsEliminatedPeriodPercent
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Provision (benefit) for income taxes, Percent
Effective Income Tax Rate Reconciliation, Percent
Cash paid for taxes
Income Taxes Paid
Finance lease, liability, current, statement of financial position [extensible list]
Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Interest income
Investment Income, Interest
Income Tax Authority
Income Tax Jurisdiction [Axis]
Fair value assets and liabilities transfers amount.
Fair Value Assets and Liabilities Transfers Amount
Fair value assets and liabilities transfers amount
Debt Securities, Available-for-Sale, Noncurrent
Long term investments available for sale
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional paid-in capital
Additional Paid in Capital, Common Stock
Accrued contract manufacturing
Accrued Contract Manufacturing Current
Accrued contract manufacturing current.
2015 Share Award Scheme
Two Thousand And Fifteen Share Award Scheme [Member]
Two thousand and fifteen share award scheme.
Deferred Tax Assets, Property, Plant and Equipment
Fixed assets
Accrued property and equipment current.
Accrued Property And Equipment Current
Accrued property and equipment
Significant Accounting Policies [Text Block]
SIGNIFICANT ACCOUNTING POLICIES
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Vesting [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted new options to purchase, shares
Deferred Tax Assets Lease Liabilities
Deferred tax assets lease liabilities.
Lease liabilities
Cybersecurity Risk Management, Strategy, and Governance [Table]
Computation of Basic and Diluted Net Loss per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Underwritten Follow-on Public Offering
Underwitten Follow-on Public Offering [Member]
Underwitten follow-on public offering.
Percentage of fee amount paid upon final payment.
Percentage of Fee Amount Paid Upon Final Payment
Percentage of fee amount paid upon final payment
Two Thousand Twenty Five Inducement Equity Incentive Plan [Member]
Two thousand twenty five inducement equity incentive plan.
2025 Inducement Equity Incentive Plan [Member]
Investments Classified by Contractual Maturity Date [Table Text Block]
Schedule of Fair Value of Available-for-Sale Investments by Contractual Maturity
Net loss per share, basic
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Number of Options, Balance
Number of Options, Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of outstanding
Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]
Schedule of Fair Value of Available for Sale Investments by Classification
Term loan.
Term Loan [Member]
Term Loan
Number of Shares Issuable Upon Vesting of Each Option
Number of shares issuable upon vesting of each option
Number of shares issuable upon vesting of each option
Total current liabilities
Liabilities, Current
Line Of Credit Facility Unused Borrowing Capacity
Line of credit facility unused borrowing capacity.
Not to draw an additional loan
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
LEASES
Lessee Operating And Financing Leases [Text Block]
Lessee operating and financing leases.
Federal
Domestic Tax Jurisdiction [Member]
Debt Securities, Available-for-Sale, Fair Value, Fiscal Year Maturity [Abstract]
Accounting Standards Update [Axis]
Additional number of common shares reserved for future issuance.
Additional Common Stock Capital Shares Reserved For Future Issuance
Number of additional shares reserved for future issuance
Consolidation Items [Domain]
Stockholders’ equity
Equity, Attributable to Parent [Abstract]
Entity Small Business
Entity Small Business
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Cross-border tax laws
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount, Total
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Net proceeds from initial public offering
Proceeds from Issuance Initial Public Offering
Total intrinsic value of options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Current Foreign Tax Expense (Benefit)
Foreign
Stockbased Compensation Expense [Member]
Stockbased compensation expense.
Stock-based Compensation Expense
STOCK-BASED COMPENSATION
Share-Based Payment Arrangement [Text Block]
Lessee, Operating Lease, Liability, to be Paid, Rolling Year Two
2027
Stock Option Exchange
Stock Option Exchange [Member]
Stock option exchange.
Office Space at 323 Allerton Avenue, South San Francisco, California
Office Space One [Member]
Office space one.
Office Space
Leases [Abstract]
Noncash or Part Noncash Acquisition, Value of Assets Acquired, Total
Acquisition of in-process research and development in accounts payable and accrued expenses
Noncash or Part Noncash Acquisition, Value of Assets Acquired
Lessee Lease Description [Line Items]
Lessee, Lease, Description [Line Items]
Amendment
Amendment Flag
Amendment Flag
At federal statutory income tax rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Personnel And Related Costs [Member]
Personnel and related costs.
Personnel and Related Costs
Finance lease cost, Interest
Finance Lease, Interest Expense
Net Loss Per Share Attributable to Common Stockholders
Earnings Per Share, Policy [Policy Text Block]
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Initial term of agreement with related party
Initial Term Of Agreement With Related Party
Initial term of agreement with related party.
Common Stock
Common Stock [Member]
Payable and accrued liabilities due to related party
Increase Decrease In Payable And Accrued Liabilities Due To Related Parties Current
Increase (decrease) in payable and accrued liabilities due to related parties current.
Cybersecurity Risk Role of Management [Text Block]
Tax credits
Tax Credit Carryforward, Amount
Long-Term Debt, Maturity, Year One
2026
Weighted Average Exercise Price, Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: accumulated depreciation
Computer Hardware and Software
Computer Hardware And Software [Member]
Computer hardware and software.
Debt Securities, Available-for-Sale [Line Items]
Excess other percentage
Pre-funded Warrants Other Percentage
Pre-funded warrants other percentage.
Entity Address, Address Line One
Entity Address, Address Line One
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Fair value assets transferred out of level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers out of Level 3
Schedule of Fair Value of Each Option Grant Using Black-Scholes Option-Pricing Model
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Earnings Per Share [Abstract]
Income Taxes
Income Tax, Policy [Policy Text Block]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Supplemental disclosure
Supplemental Cash Flow Information [Abstract]
Foreign Currency Transactions
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Silicon Valley Bank
Silicon Valley Bank [Member]
Silicon valley bank.
Balance Sheet Location
Statement of Financial Position Location, Balance [Axis]
Worldwide changes in unrecognized tax benefits
Effective Income Tax Rate Reconciliation, Worldwide Changes in Unrecognized Tax Benefits, Percent
Effective income tax rate reconciliation, worldwide changes in unrecognized tax benefits, percent.
Operating lease ROU assets
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Less: imputed interest
Finance Lease, Liability, Undiscounted Excess Amount
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Issuance Of Common Stock And Pre Funded Warrants In Connection With Equity Offerings Net Of Underwriter Discounts And Issuance Costs
Issuance of common stock and pre funded warrants in connection with equity offerings net of underwriter discounts and issuance costs.
Issuance of common stock and pre-funded warrants in connection with equity offerings, net of underwriter discounts ($3,795 thousand) and issuance costs ($567 thousand)
Document Type
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Entity Central Index Key
Entity Central Index Key
Debt Securities, Available-for-Sale [Table Text Block]
Financial Assets Measured at Fair Value on Recurring Basis
Percentage of loan agreement amount to be held in collateral account
Percentage of Loan Agreement Amount to be Held in Collateral Account
Percentage of loan agreement amount to be held in collateral account.
Long Term Investment Corporate Debt Securities [Member]
Long term investment corporate debt securities.
Long Term Investment Corporate Debt Securities
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Term loan non current.
Term Loan Non Current
Total term loan, net of current portion
Total term loan, net of current portion
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Excluding Exchange Rate Effect, Including Discontinued Operation
Net (decrease) in cash, cash equivalents and restricted cash
Commercial Antibody Agreement
Commercial Antibody Agreement [Member]
Commercial antibody agreement.
Subsequent Event Type [Domain]
Subdequent Event
Antidilutive securities excluded from computation of earnings per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Balance Sheet Related Disclosures [Abstract]
Common stock, par value
Common Stock, Par or Stated Value Per Share
Accounting Standards Update [Domain]
Pre-funded Warramts
Pre-funded warrants [Member]
Pre-funded warrants.
Combined Voting Power Percentage
Pre-funded Warrants Exceed Combined Voting Power Percentage
Pre-funded warrants exceed combined voting power percentage.
Proceeds from offering allocated to pre-funded warrants
Proceeds from Issuance of Warrants
Base Rate [Member]
Base Rate
Weighted Average Remaining Contractual Life (Years), Outstanding Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Expected stock price volatility, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Debt Securities, Available-for-Sale
Fair Value
Total available-for-sale investments
Finance Lease, Liability, to be Paid, Rolling Year Two
2027
Indemnification Agreement
Indemnification Agreement [Member]
Document Financial Statement Error Correction [Flag]
Loan Agreement with Lenders
Percentage Of Loan Agreement With Lenders
Percentage of loan agreement with lenders.
Number of Options, Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Debt Disclosure [Abstract]
US State
State and Local Income Tax Expense (Benefit), Continuing Operations
State and Local Income Tax Expense (Benefit), Continuing Operations, Total
Pre Funded Warrants Issued And Outstanding [Member]
Pre-funded warrants issued and outstanding.
Pre Funded Warrants Issued And Outstanding
Current Fiscal Year End Date
Current Fiscal Year End Date
Debt Instrument [Table]
Schedule of Long-Term Debt Instruments [Table]
Accrued cumulative dividends on the Series A, Series B and Series C convertible preferred stock
Preferred Stock, Amount of Preferred Dividends in Arrears
Entity Address, State or Province
Entity Address, State or Province
Number of share option
Number of RSUs, Balance
Number of RSUs, Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of units outstanding and unvested
Line of Credit Facility, Remaining Borrowing Capacity
Draw an additional loan
Accrued expenses and other current liabilities
Increase (Decrease) in Other Accrued Liabilities
Financial Liabilities Fair Value Disclosure, Total
Financial liabilities fair value disclosure
Financial Liabilities Fair Value Disclosure
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Total comprehensive loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Unrealized Gains
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Common stock reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Net Operating Loss And Tax Credit Carryforwards [Line Items]
Net Operating Loss And Tax Credit Carryforwards [Line Items]
Net operating loss and tax credit carryforwards.
Components of Accrued Expenses and Other Current Liabilities
Schedule Of Accrued Expenses And Other Current Liabilities Table [Text Block]
Schedule of accrued expenses and other current liabilities.
Short-term investment commercial paper.
Short-term Investment Commercial Paper [Member]
Short Term Investment Commercial Paper
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State income taxes, net of federal effect
Summary of Share-Based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Nontaxable or nondeductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
2020 Equity Incentive Plan
Twenty Thousand And Twenty Equity Incentive Plan [Member]
twenty thousand and twenty equity incentive plan.
Schedule of Components of Deferred Tax Assets
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive gain (loss), net of tax:
Subsequent Event [Member]
Subsequent Event
Stock Purchase Agreement [Member]
Stock purchase agreement.
Stock Purchase Agreement
Annual interest rate of additional payments over life of lease.
Annual Interest Rate of Additional Payments Over Life Of Lease
Annual interest rate of additional payments over life of lease
Other assets
Other Assets, Noncurrent
Total other assets
Debt Securities, Available-for-Sale, Current
Short term investments available for sale
Antidilutive Securities
Antidilutive Securities [Axis]
Other Liability, Current, Related Party [Extensible Enumeration]
Unrecognized Tax Benefits, Increase Resulting from Settlements with Taxing Authorities
Settlements
Percentage of eligible compensation withheld
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Fair value of RSUs vested
Interest Expense, Debt, Total
Interest Expense, Debt
Interest expense
Rate benefit of reorganization
Income Tax Reconciliation Rate Benefit Of Reorganization
Income tax reconciliation rate benefit of reorganization.
Proceeds from Sale of Debt Securities, Available-for-Sale
Maturities of investments
Debt Instrument, Unamortized Discount, Total
Debt Instrument, Unamortized Discount
Less: unamortized debt issuance costs
Less: unamortized debt issuance costs
State
State and Local Jurisdiction [Member]
Supplemental Cash Flow Information Related To Leases Table [Text Block]
Supplemental cash flow information related to leases.
Supplemental Cash Flow Disclosures for Cash Paid for Leases
Option to extend term
Lessee, Finance Lease, Option to Extend
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss)
Finite-Lived Intangible Assets, Major Class Name [Domain]
Permitted issuance of common stock which as maximum no of shares for issuance under the plan, which includes options, awards, and RSUs.
Permitted Issuance of Common Stock
Number of permitted issuance of share option
Lessee, Operating Lease, Liability, to be Paid, Rolling Year Five
2030
Markup cost in percentage
Related Party Markup Cost Percentage
Related party markup cost percentage.
Option to extend term
Lessee, Operating Lease, Option to Extend
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Deferred tax expense (benefit):
Issuance Costs
Issuance Costs Policy [Policy Text Block]
Issuance costs.
Debt Instrument, Maturity Date
Maturity date
Minimum
Minimum [Member]
Weighted-Average Grant Date Fair Value, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant-date fair value per share, RSUs granted
Shares Issuance Of Common Stock And Pre Funded Warrants In Connection With Equity Offerings Net Of Underwriter Discounts And Issuance Costs
Shares issuance of common stock and pre funded warrants in connection with equity offerings net of underwriter discounts and issuance costs.
Issuance of common stock and pre-funded warrants in connection with equity offerings, net of underwriter discounts ($3,795 thousand) and issuance costs ($567 thousand), shares
Financial Instrument [Axis]
Current assets:
Assets, Current [Abstract]
Level 3
Fair Value, Inputs, Level 3 [Member]
Segment Reporting [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Returned
Share based compensation arrangement by share based payment award number of shares available for grant returned.
Shares Available to Grant, Returned
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Financial Assets Measured at Fair Value on Recurring Basis
Current liabilities:
Liabilities, Current [Abstract]
Oxford finance and silicon valley bank loan agreement.
Oxford Finance And Silicon Valley Bank Loan Agreement [Member]
Oxford-SVB Loan Agreement
Change related to acquisitions
Valuation Allowance, Deferred Tax Asset, Change Related to Acquisitions
Valuation allowance, deferred tax asset, change related to acquisitions.
Related Party Transactions [Abstract]
Balance, shares
Balance, shares
Shares, Outstanding
Operating Loss Carryforwards, Total
Net operating losses
Operating Loss Carryforwards
Lessee, Operating Lease, Renewal Term
Lessee operating lease renewal term
Prepaid Expense, Noncurrent, Total
Prepaid Expense, Noncurrent
Long-term prepaid expenses
Proceeds from Stock Plans
Proceeds from issuance of common stock under employee stock purchase plan
Commitments and Contingencies
Commitments and contingencies (Note 13)
Leases
Lessee, Leases [Policy Text Block]
Weighted-Average Grant Date Fair Value, Balance
Weighted-Average Grant Date Fair Value, Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted-average grant-date fair value per share, restricted stock units granted
Fixed rate.
Fixed Rate [Member]
Fixed Rate
Shares Issued, Shares, Share-based Payment Arrangement, after Forfeiture, Total
Issuance of common stock under equity incentive plans, shares
Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture
Common Stock Reserved for Future Issuance
Schedule Of Common Stock Reserved For Future Issuance Table [Text Block]
Schedule of common stock reserved for future issuance.
General and Administrative
General and Administrative Expense [Member]
Total lease liabilities
Operating lease liabilities
Operating Lease, Liability
Auditor Firm ID
Auditor Firm ID
Debt Instrument, Basis Spread on Variable Rate
Basis spread rate
Preferred stock, cumulative dividends percentage
Preferred Stock, Dividend Rate, Percentage
Short-Term Debt, Total
Short-Term Debt
Term loan, current
Long-Term Debt, Maturity, Year Two
2027
Finance current lease liabilities
Finance lease liabilities, current
Finance Lease, Liability, Current
Lessee Lease Description [Table]
Lessee, Lease, Description [Table]
Weighted average discount rate
Finance Lease, Weighted Average Discount Rate, Percent
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Weighted Average Remaining Contractual Life (Years), Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Office Space at 866 Malcolm Road, Burlingame, California
Office Space [Member]
Office space.
Weighted-average shares of common stock outstanding, basic
Weighted-average shares of common stock used to compute net loss per share, basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Amount, after accumulated unaccreted final payment costs.
Term Loan Final Payment Cost
Less: unaccreted final payment costs
Segment Reporting, Expense Information Used by CODM, Description
Share-Based Payment Arrangement, Plan Modification, Incremental Cost
Incremental expense
Schedule of Statutory and Effective Income Tax Rate Reconciliation
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures, Total
Number of Options, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Finance lease, right-of-use asset, statement of financial position [extensible list]
Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]
SUBSEQUENT EVENTS
Subsequent Events [Text Block]
Long-Term Debt
Total future maturities
RELATED-PARTY TRANSACTIONS
Related Party Transactions Disclosure [Text Block]
Cash
Bank account cash
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Debt Instrument, Interest Rate Terms
Interest rate terms
Research and Development Services Agreement
Research And Development Services Agreement [Member]
Research and development services agreement.
Variable Rate [Domain]
Research & other credits
Deferred Tax Asset, In-Process Research and Development
Change related to OCI
Valuation Allowance, Deferred Tax Asset, Change Related to Other Comprehensive Income
Valuation allowance, deferred tax asset, change related to other comprehensive income.
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Total stockholders’ equity
Balance
Balance
Equity, Attributable to Parent
Payments to Acquire Investments, Total
Payments to Acquire Investments
Purchase of investments
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Crystal Bioscience Inc
Crystal Bioscience Inc [Member]
Crystal Bioscience Inc.
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Existence of option to extend
Lessee, Operating Lease, Existence of Option to Extend [true false]
Statement of Stockholders' Equity [Abstract]
Lessee, operating lease commencing end date
Lessee Operating Lease Commencing End Date
Lessee, operating lease commencing end date.
Shares Available to Grant, Canceled/forfeited
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Canceled
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Canceled
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Long-Term Debt, Maturity, Year Five
2030
Over Allotment Option
Over-Allotment Option [Member]
Leasehold Improvements
Leasehold Improvements [Member]
FAIR VALUE OF FINANCIAL INSTRUMENTS
Fair Value Disclosures [Text Block]
Fixed assets
Deferred Tax Liabilities Property Plant And Equipment1
Deferred tax liabilities, property, plant and equipment.
Debt Instrument, Name
Debt Instrument, Name [Domain]
Other Assets, Current
Other current assets
ScalmiBio, Inc
Scalmi Bio Inc [Member]
ScalmiBio, Inc.
Total accrued expenses and other current liabilities
Accrued expenses and other current liabilities
Accrued Liabilities and Other Liabilities
Long-Term Debt, Maturity, Year Four
2029
Schedule of Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Stock options
Deferred Tax Assets Stock Options
Deferred tax assets stock options.
Plan Name
Plan Name [Domain]
Lessee, Operating Lease, Liability, to be Paid, Next Rolling 12 Months
2026
Increase (Decrease) in Other Operating Assets, Total
Increase (Decrease) in Other Operating Assets
Other assets
Interest expense
Interest Expense, Operating and Nonoperating
Interest Expense, Total
Interest and investment receivables
Interest and Investment Receivables Current
Interest and investment receivables current.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Entity
Entity [Domain]
Credit Facility [Axis]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Impairment, Long-Lived Asset, Held-for-Use
Impairment of long-lived assets
Impairment charge
Total impairment charge
Current State and Local Tax Expense (Benefit)
US State
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Vesting terms
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Variable lease cost and other, net
Variable Lease Cost And Other Net
Variable lease cost and other, net.
Related Party
Related and Nonrelated Parties [Axis]
At-the-Market Equity Offering
At-the-Market Equity Offering [Member]
At-the-market equity offering.
Other
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Foreign
Foreign Tax Jurisdiction [Member]
Fair value liabilities transferred into level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers Into Level 3
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Collaboration Agreement
Collaboration Agreements [Member]
Collaboration Agreements.
Preclinical Costs [Member]
Preclinical costs.
Preclinical Costs
Stock Options Issued and Outstanding
Stock Options Issued And Outstanding [Member]
Stock options issued and outstanding.
February Two Thousand and Twenty Six Registered Offering [Member]
February two thousand and twenty six registered offering.
February 2026 Offering
Entity Address, City or Town
Entity Address, City or Town
Debt instrument outstanding balance of loan threshold required to be collateral.
Debt Instrument Outstanding Balance of Loan Threshold Required to be Collateral
Outstanding balance of loan threshold at which Intellectual Property becomes collateral
Number of reportable segment
Number of Reportable Segments
Security Exchange Name
Security Exchange Name
Credit Facility [Domain]
Purchase Obligation, to be Paid, Year Two and Three, Total
Purchase Obligation, to be Paid, Year Two and Three
Manufacturing and service contracts, 2027-2028
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property and equipment, gross
Property, Plant and Equipment, Gross
Term loan unamortized final payment.
Term Loan Unamortized Final Payment
Less: unaccreted final payment costs
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Current tax expense (benefit):
Deferred offering costs
Deferred Offering Costs
Other Pharmaceutical Manufacturing Contract
Other Pharmaceutical Manufacturing Contract [Member]
Other pharmaceutical manufacturing contract.
Loss before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Deduction of Debt Issuance Costs
Deduction of Debt Issuance Costs
deduction of debt issuance costs
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign tax effects
Line Of Credit Facility Additional Borrowing Capacity At Lenders Discretion
Line of credit facility additional borrowing capacity at lenders discretion.
Additional borrowing capacity at lender's discretion
Gross proceeds from issuance of common stock
Gross Proceeds From Issuance Of Common Stock
Gross proceeds from issuance of common stock.
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Cash, cash equivalents and restricted cash at beginning of year
Cash, cash equivalents and restricted cash at end of period
Total cash, cash equivalents and restricted cash
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activity
Statistical Measurement
Statistical Measurement [Domain]
WuXi Biologics Ireland, Limited [Member]
WuXi biologics ireland, limited.
WuXi Biologics Ireland, Ltd
Common stock exercise price
Class of Warrant or Right, Exercise Price of Warrants or Rights
Total current assets
Assets, Current
Stock-based compensation expenses
Total stock-based compensation expense
Share-Based Payment Arrangement, Expense
Purchase of property and equipment in accounts payable and accrued expenses
Noncash or Part Noncash Acquisition, Fixed Assets Acquired
Document Period End Date
Document Period End Date
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of Options, Exercisable at December 31, 2025
Registration Payment Arrangement [Table Text Block]
Summary of Other Contractual Obligations and Other Commitments from Manufacturing and Service Contracts
Number of shares purchased
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Purchased for Award
Finance lease, liability, noncurrent, statement of financial position [extensible list]
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Operating lease, liability, current, statement of financial position [extensible list]
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Operating lease right-of-use assets and leasehold improvements
Operating Lease Right Of Use Asset And Leasehold Improvements Fair Value
Operating lease right of use asset and leasehold improvements fair value.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Significant accounting policies.
Statement of Financial Position [Abstract]
Restricted Stock Units
Restricted Stock Units (RSUs) [Member]
Loss Contingency Nature
Loss Contingency Nature [Axis]
Loss Contingency, Nature
Loss Contingency, Nature [Domain]
Tallac Therapeutics
Tallac Therapeutics [Member]
Tallac therapeutics.
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Vesting [Axis]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract]
Reconciliation of cash and cash equivalents and restricted cash:
Class of Stock
Class of Stock [Axis]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Milestone payments related to clinical and regulatory
Milestone Payments Related To Clinical And Regulatory
Milestone payments related to clinical and regulatory.
Current Income Tax Expense (Benefit)
Total current tax expense (benefit)
Tranche C.
Tranche C [Member]
Tranche C
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Number of pending or threatened litigation
Number of pending or threatened litigation
Number of pending or threatened litigation
Finance Lease, Liability, Payment, Due [Abstract]
Finance Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Changes in tax laws or rates
Total liabilities
Liabilities
Short-term investment asset backed securities.
Short-term Investment Asset Backed Securities [Member]
Short Term Investment Asset-Backed Securities
Financial Instruments [Domain]
Follow-on Public Offering
Follow On Public Offering [Member]
Follow-on public offering.
Foreign
Foreign Income Tax Expense (Benefit), Continuing Operations
Foreign Income Tax Expense (Benefit), Continuing Operations, Total
Share options, service period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Requisite Service Period
Shares Available to Grant, Granted
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Granted
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Granted
Sophia Randolph [Member]
Sophia Randolph.
Sophia Randolph
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Foreign tax effects
Restricted Cash, Total
Restricted Cash
Restricted cash deposits
Secured term loan facility.
Secured Term Loan Facility [Member]
Secured Term Loan Facility
Finance lease cost, Amortization of right-of-use assets
Finance Lease, Right-of-Use Asset, Amortization
Variable Rate [Axis]
Prepaid Expense and Other Assets, Current [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Exchange Offer Number of Options Exchanged
Share based compensation arrangement by share based payment award exchange offer number of options exchanged.
Number of shares exchanged
Weighted-average shares of common stock outstanding, diluted
Weighted-average shares of common stock used to compute net loss per share, diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Amount of amortization expense for right-of-use asset from operating and finance leases.
Operating Finance Lease Right Of Use Asset Amortization Expense
Non-cash lease costs
Entity File Number
Entity File Number
Unrealized gain (loss) on available-for-sale investments
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized gain on available-for-sale investments
Number of lenders
Number of Lenders
Number of lenders.
Accounting Standards Update 2023-07 [Member]
ASU No. 2023-07
Cover
Cover [Abstract]
Expected stock price volatility, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Schedule of Maturities of Operating and Finance Lease Liabilities
Lessee Operating And Financing Lease Liability Maturity Table [Text Block]
Lessee operating and financing lease liability maturity.
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total prepaid expenses and other current assets
Number of RSUs, Canceled/forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Maximum percentage of additional shares reserved for future issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Fair value liabilities transferred out of level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers out of Level 3
BALANCE SHEET COMPONENTS
Supplemental Balance Sheet Disclosures [Text Block]
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Rolling Year Five
Summary of Valuation Allowance [Table Text Block]
Schedule of Reconciliation of Total Change in Valuation Allowance
Net operating losses, Expiration Years
Operating Loss Carryforwards Expiration Period
Operating loss carryforwards expiration period.
Share-based compensation, number of shares authorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of operating segment
Number of Operating Segments
Sale of Stock
Sale of Stock [Domain]
Segment Reporting Disclosure [Text Block]
Segment Reporting
General and Administrative Expense
General and administrative expenses
General and administrative expenses
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Total
Number of Options, Canceled/forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period
Subsequent Event [Table]
Other
Deferred Tax Assets, Other
Incremental prepayment amount.
Incremental Prepayment Amount
Incremental prepayment amount
Performance-based Restricted Stock Issued And Outstanding [Member]
Performance-based Restricted Stock Issued And Outstanding [Member]
PSUs Issued and Outstanding
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Changes in tax laws or rates
Accrued clinical and nonclinical study costs
Accrued Clinical And Non Clinical Costs Current
Accrued clinical costs and non clinical costs current.
Other Commitments [Table Text Block]
Summary of Other Contractual Obligations and Other Commitments from Manufacturing and Service Contracts
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Total
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss
Accrued interest receivable, investment
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted Accounting Pronouncements
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Employee Stock Purchase Plan Shares Authorized for Future Issuance
Employee Stock Purchase Plan Shares Authorized For Future Issuance [Member]
Employee stock purchase plan shares authorized for future issuance.
Gain (Loss) on Disposition of Assets
Gain (Loss) on Disposition of Assets, Total
Loss on disposal of fixed asset
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Significant accounting policies.
Nontaxable or nondeductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Short-term investment U.S. government agencies debt securities.
Short-term Investment U S Government Agencies Debt Securities [Member]
Short Term Investment U.S. Government Agency Securities
Short-term investment U.S. treasury securities.
Short-term Investment U S Treasury Securities [Member]
Short Term Investment U.S. Treasury Securities
Risk-free interest rate, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Tranche D.
Tranche D [Member]
Tranche D
Income (Loss) from Continuing Operations before Income Taxes, Domestic
United States
Area of operating lease
Lessee Area Of Operating Lease
Lessee area of operating lease.
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Recognized interest and penalties expense (benefit) related to unrecognized tax benefits
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Long-Term Investments, Total
Long-Term Investments
Long-term investments
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Operating current lease liabilities
Lease liabilities: current
Operating lease liabilities, current
Depreciation, Depletion and Amortization, Total
Depreciation and amortization
Depreciation, Depletion and Amortization
Contractual Obligation, Fiscal Year Maturity [Table Text Block]
Schedule of Future Maturities Under the Loan Agreement
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Net deferred tax assets
Deferred Tax Assets, Net
Short-Term Investments, Total
Short-Term Investments
Short-term investments
Total operating expenses
Operating Expenses
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Commitments and contingencies.
Research and development costs
Research and development expenses
Research and development expenses
Research and development
Impairment charges
Asset Impairment Charges
Total impairment charge
Impairment of long-lived assets
Summary of net operating loss and tax credit carryforwards.
Summary Of Net Operating Loss And Tax Credit Carryforwards [Text Block]
Summary of Net Operating Loss and Tax Credit Carryforwards
Convertible Preferred Stock
Convertible Preferred Stock [Member]
Schedule of Income Tax Provision (Benefit)
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Statement of Cash Flows [Abstract]
Current Federal Tax Expense (Benefit)
US Federal
Stock Issued During Period, Value, New Issues
Issuance of common stock through ATM offering, net of commissions
Summary of Share Option Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Exclusive Equity Agreement
Exclusive Equity Agreement [Member]
Exclusive equity agreement.
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock-based compensation
Reconciliation of Assets from Segment to Consolidated [Table]
Equity [Text Block]
STOCKHOLDERS' EQUITY
NET LOSS PER SHARE ATTRIBUTABLE TO COMMON STOCKHOLDERS
Earnings Per Share [Text Block]
Lessee operating lease leasehold improvements.
Lessee Operating Lease Leasehold Improvements
Lessee operating lease leasehold improvements
Two Thousand Twenty Equity Incentive Plan and Two Thousand Twenty-Five Inducement Equity Incentive Plan [Member]
Two thousand twenty equity incentive plan and two thousand twenty-five inducement equity incentive plan.
2020 Plan and 2025 Plan
Right Of Use Asset Acquired Under Leases [Abstract]
Right-of-use asset acquired under leases.
Right-of-use asset (modified) acquired under leases
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Unit (RSU)Activity
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net loss
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Outstanding Options Aggregate Intrinsic Value, Balance
Income Tax Expense (Benefit), Continuing Operations, by Jurisdiction [Abstract]
Total income tax expense (benefit)
Common stock shares, Percentage
Common Stock Shares Outstanding Percentage
Common stock shares outstanding percentage.
Operating lease cost
Operating Lease, Cost
Long term investment US treasury securities.
Long Term Investment US Treasury Securities [Member]
Long Term Investment U.S. Treasury Securities
Long term investment asset backed securities.
Long Term Investment Asset Backed Securities [Member]
Long Term Investment Asset-Backed Securities
Restricted Stock Issued And Outstanding [Member]
Restricted Stock Issued And Outstanding [Member]
RSUs Issued and Outstanding
Expected dividend rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Tollnine
Tollnine [Member]
Tollnine.
Contractual Obligation, to be Paid, Year Two and Three, Total
Contractual Obligation, to be Paid, Year Two and Three
Contractual Obligation, 2027-2028
Net Operating Loss And Tax Credit Carryforwards [Table]
Net Operating Loss And Tax Credit Carryforwards [Table]
Net operating loss and tax credit carryforwards.
Manufacturing and service contracts, Total
Future purchase obligations
Purchase Obligation
Operating cash flows from operating leases
Operating Lease, Payments
Outstanding Options Aggregate Intrinsic Value, Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Assets
Assets [Abstract]
Unvested early exercised options
Share Based Compensation Arrangement By Share Based Payment Award Options Nonvested Exercised
Share based compensation arrangement by share based payment award options nonvested exercised.
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Repayments of Debt
Principal payments on term loan
Amortization of Debt Issuance Costs and Discounts, Total
Amortization of Debt Issuance Costs and Discounts
Accretion of term loan discount and issuance costs
Long-Term Debt, Fiscal Year Maturity [Abstract]
Schedule of Prepaid Expenses and Other Current Assets
Components of Prepaid Expenses and Other Current Assets [Table Text Block]
Components of prepaid expenses and other current assets.
Document Fiscal Year Focus
Document Fiscal Year Focus
Change related to continuing operations
Valuation Allowance, Deferred Tax Asset, Change Related to Continuing Operations
Valuation allowance, deferred tax asset, change related to continuing operations.
Percentage of increase of annual rent.
Percentage Of Increase Of Annual Rent
Percentage of increase of annual rent
Investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Lapses in statutes of limitations
Unrecognized Tax Benefits, Reduction Resulting from Lapse of Applicable Statute of Limitations
Schedule Components of Loss Before Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Research and Development
Research and Development Expense [Member]
US Federal
International
Deferred Federal Income Tax Expense (Benefit)
Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture, Total
Issuance of common stock under equity incentive plans
Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture
Stanford Junior University.
Stanford University
Stanford University [Member]
Deferred tax assets:
Components of Deferred Tax Assets [Abstract]
Impairment losses on available-for-sale investments
Impairment Losses on Available-for-sale Investments
Impairment losses on available-for-sale investments.
Purchase Obligation, to be Paid, Year One
Manufacturing and service contracts, 2026
Accounting Standards Update 2020-06 [Member]
ASU No. 2020-06
Proceeds from exercise of stock options under equity incentive plan
Proceeds from Stock Options Exercised
Fair Value Disclosures [Abstract]
Concentration Of Credit Risk, Credit Losses And Other Risks And Uncertainties
Concentration Of Credit Risk Credit Losses And Other Risks And Uncertainties Policy [Text Block]
Concentration of credit risk, credit losses and other risks and uncertainties.
Commitments and Contingencies Disclosure [Abstract]
Other Assets Noncurrent Other
Amount of other assets noncurrent other.
Other assets
Debt Instrument
Debt Instrument [Axis]
Share-Based Payment Arrangement [Abstract]
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Unrecognized share-based compensation expense
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Finance Lease, Liability, to be Paid, Next Rolling 12 Months
2026
Sale of Stock
Sale of Stock [Axis]
Shares Available to Grant, Authorized
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Authorized
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Authorized.
Intellectual Property [Member]
Intellectual Property
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by investing activities
Fair value assets transferred into level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3
Weighted average remaining lease term (in years)
Finance Lease, Weighted Average Remaining Lease Term
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Weighted Average Exercise Price, Canceled/forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted-Average Grant Date Fair Value, Canceled/forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Money Market Funds [Member]
Money Market Funds
Related Party
Related and Nonrelated Parties [Domain]
INCOME TAXES
Income Tax Disclosure [Text Block]
Nonrefundable license royalty and patent expenses
Nonrefundable License Royalty And Patent Expenses
Nonrefundable license royalty and patent expenses.
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Total
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Beginning Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Ending Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss
Allowance for credit losses
Other Liabilities, Noncurrent, Total
Other non-current liabilities
Other Liabilities, Noncurrent
Finance Lease, Right-of-Use Asset, after Accumulated Amortization, Total
Finance lease ROU assets
Finance Lease, Right-of-Use Asset, after Accumulated Amortization
Finance lease right-of-use assets
Legal Entity
Legal Entity [Axis]
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, after Year One Through Five
Maturing after one year through five years
Changes in operating assets and liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Lessee operating lease leasehold improvements additional payments.
Lessee Operating Lease Leasehold Improvements Additional Payments
Lessee operating lease leasehold improvements additional payments
Schedule of Components of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Letters of Credit Outstanding, Amount
Letter of credit
Weighted Average Exercise Price, Balance
Weighted Average Exercise Price, Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Common stock exercise price of shares purchased per share
Stock option modification.
Stock Option Modification [Member]
Stock Option Modification
Income Tax Disclosure [Abstract]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Unrecognized tax benefits
Unrecognized Tax Benefits
Beginning balance
Ending balance
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Payment for offering related expense
Payment For Offering Cost
Payment for offering cost.
Measurement Frequency
Measurement Frequency [Domain]
Operating lease, liability, noncurrent, statement of financial position [extensible list]
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Income Statement Location
Statement of Income Location, Balance [Axis]
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Trading Symbol
Line Of credit facility available borrowing capacity upon achievement of milestones.
Line Of Credit Facility Available Borrowing Capacity Upon Achievement of Milestones
Available borrowing capacity upon achievement of milestones
Schedule Of Related Party Transactions By Related Party [Table]
Related Party Transaction [Table]
Risk-free interest rate, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Subsequent Event Type [Axis]
Employee-related Liabilities, Current, Total
Accrued compensation and related expenses
Employee-related Liabilities, Current
Financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Fair Value on Recurring Basis
Fair Value, Recurring [Member]
Total lease payments
Lessee, Operating Lease, Liability, to be Paid
Total lease payment
Other than Temporary Impairment Losses, Investments
Impairment losses on available-for-sale investments
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research & development credits
Research & development credits
At The Market Offering [Member]
At the market offering.
ATM Offering
Amount, after accumulated unaccreted final payment costs.
Term Loan Final Payment Costs
Less: unaccreted final payment costs
Less: unaccreted final payment costs
Equity Components
Equity Components [Axis]
Lessee operating lease expiration period.
Lessee Operating Lease Expiration Period
Lease operating lease expiration period
Equity Component
Equity Component [Domain]
Summary of Shares Available for Grant
Share-Based Payment Arrangement, Activity [Table Text Block]
Asset Class [Axis]
Schedule of Future Minimum Lease Commitments under Operating Leases
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Contractual Obligation, to be Paid, Year Four and Five, Total
Contractual Obligation, to be Paid, Year Four and Five
Contractual Obligation, 2029-2030
Document Annual Report
Document Annual Report
Purchase Obligation, to be Paid, Year Four and Five, Total
Purchase Obligation, to be Paid, Year Four and Five
Manufacturing and service contracts, 2029-2030
Prepaid Insurance
Prepaid insurance
Debt instrument covenant debt default rate.
Debt Instrument Covenant Debt Default Rate
Debt default rate
Initial Public Offering
IPO [Member]
Issuance of common stock under employee stock purchase plan, shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Effective Income Tax Rate Reconciliation, Rate Benefit of Reorganization, Percent
Effective income tax rate reconciliation, rate benefit of reorganization, percent.
Rate benefit of reorganization
Share options, maximum term
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation, Depletion and Amortization, Nonproduction
Depreciation
Statement of Comprehensive Income [Abstract]
Maximum
Maximum [Member]
Statistical Measurement
Statistical Measurement [Axis]
Weighted Average Exercise Price, Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Cumulative preferred stock dividend convertible shares issued upon conversion
Cumulative Preferred Stock Dividend Convertible Shares Issued Upon Conversion
Cumulative preferred stock dividend convertible shares issued upon conversion.
Prepaid Expense, Current
Prepaid Expense, Current, Total
Prepaid expenses
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Common stock, $0.001 par value; 1,000,000,000 shares authorized as of December 31, 2025 and December 31, 2024; 54,388,022 and 53,052,912 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively
Principal payments on finance leases
Financing cash flows from finance leases
Finance Lease, Principal Payments
Agreement Termination Date
Agreement termination date
Agreement termination date
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Laboratory Equipment
Equipment [Member]
Deferred Tax Assets, Operating Loss Carryforwards, Total
Loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State income taxes, net of federal effect
Stock options authorized for future issuance.
Stock Options Authorized For Future Issuance [Member]
Stock Options Authorized for Future Issuance
Entity Public Float
Entity Public Float
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Exchange offer percentage of total shares eligible
Share Based Compensation Arrangement By Share Based Payment Award Exchange Offer Percentage Of Total Shares Eligible
Share based compensation arrangement by share based payment award exchange offer percentage of total shares eligible.
Finance lease, description
Lessee, Finance Lease, Description
Finite-Lived Intangible Assets by Major Class [Axis]
Clinical And Development Costs [Member]
Clinical and development costs.
Clinical and Development Costs
Lease operating lease commencement period two.
Lease Operating Lease Commencement Period Two
Lease operating lease commencement period for second premises
Share-based Compensation, lower of closing price, percentage
Share Based Compensation Arrangement By Share Based Payment Award Purchase Of Common Sock At Lower Of Closing Price Percentage
Share-based compensation arrangement by share-based payment award, purchase of common sock at lower of closing price, percentage.
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent, Total
Cross-border tax laws
Phantom Share Units (PSUs) [Member]
Phantom Share Units
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Entity Registrant Name
Entity Registrant Name
TERM LOAN
Debt Disclosure [Text Block]
Right-Of-Use Asset Modified Under Finance Lease
Right-of-use asset modified under finance lease.
Finance leases
Right-of-use asset (modified) acquired under finance leases
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Losses
Entity Voluntary Filers
Entity Voluntary Filers
ESPP
Twenty Thousand And Twenty Employee Stock Purchase Plan [Member]
Twenty thousand and twenty employee stock purchase plan.
Other income (expense), net
Other Nonoperating Income (Expense), Total
Other income (expense), net
Other Nonoperating Income (Expense)
Deferred State and Local Income Tax Expense (Benefit)
US State
Subsequent Events [Abstract]
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Income Tax Expense (Benefit)
Income tax provision
Total provision (benefit) for income taxes
Income tax expense
Measurement Frequency
Measurement Frequency [Axis]
Net proceeds received
Proceeds from Issuance of Common Stock
Proceeds from ATM offering, net of commissions
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Selexis SA [Member]
Selexis SA
Selexis SA.
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated other comprehensive income
Consolidation Items [Axis]
Share-based compensation, authorized amount
Share Based Compensation Arrangement By Share Based Payment Award Authorized Amount
Share-based compensation arrangement by share-based payment award, authorized amount.
US Federal
Federal Income Tax Expense (Benefit), Continuing Operations
Federal Income Tax Expense (Benefit), Continuing Operations, Total
Payments to Acquire Property, Plant, and Equipment, Total
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Number of RSUs, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of units. granted
Long-term investments.
Long-term Investments [Member]
Long-term Investments
Total assets
Assets
Assets
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Weighted Average Remaining Contractual Life (Years), Outstanding Options Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Income Statement [Abstract]
Operating cash flows from finance leases
Finance Lease, Interest Payment on Liability
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Aggregate Intrinsic Value, Balance
Outstanding Options Aggregate Intrinsic Value, Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Stock-based Compensation Expense
Share-Based Payment Arrangement [Policy Text Block]
Deferred Income Tax Expense (Benefit)
Total deferred tax expense (benefit)
Accretion of Final Payment.
Accretion of Final Payment
Accretion of final payment
Cash Cash Equivalents And Investments [Member]
Cash cash equivalents and investments.
Cash, Cash Equivalents and Investments
Shares issued
Issuance of common stock and pre-funded warrants in connection with equity offerings, net of underwriter discounts and issuance costs, shares
Issuance of common stock through ATM offering, net of commissions, shares
Convertible preferred stock, shares authorized
Temporary Equity, Shares Authorized
Income Tax Reconciliation, Worldwide Changes in Unrecognized Tax Benefits
Income tax reconciliation, worldwide changes in unrecognized tax benefits.
Worldwide changes in unrecognized tax benefits
Number of RSUs, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of RSUs, Vested
Net loss per share, diluted
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Long-term investment U.S. government agencies debt securities.
Long Term Investment U S Government Agencies Debt Securities [Member]
Long-term Investment U.S. Government Agency Securities
Registered Offering
Registered Offering [Member]
Registered offering.
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Summary of Disaggregated Segment Expenses Split between R&D and G&A Costs
Operating Segments
Operating Segments [Member]
Effective Income Tax Rate Reconciliation, Percent [Abstract]
City Area Code
City Area Code
Exchange offer expired date
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Date
Line of credit facility available borrowing capacity at lender's discretion.
Line Of Credit Facility Available Borrowing Capacity at Lender's Discretion
Available borrowing capacity at lender's discretion
Auditor Name
Auditor Name
Restricted Cash and Cash Equivalents, Current, Total
Restricted Cash and Cash Equivalent, Current
Restricted cash (included in other assets)
Contingency fee
Debt Instrument, Fee Amount
Finance lease liability, noncurrent
Finance Lease Liability, Noncurrent
Undesignated Preferred Stock
Undesignated Preferred Stock [Member]
Undesignated preferred stock.
Term loan, principal amount
Debt Instrument, Face Amount
Debt instrument, face amount
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research & development credits
Accrued expenses
Deferred Tax Assets Accrued Expenses
Deferred tax assets accrued expenses.
Finance Lease, Liability, to be Paid, Rolling Year Three
2027
Issuance of common stock under employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Underwriter discounts
Payments for Underwriter Discounts
Payments for underwriter discounts.
Weighted average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Total lease costs
Lease, Cost
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Finance leases
Right-of-Use Asset Obtained in Exchange for Finance Lease Liability
Right-of-use asset (modified) acquired under finance leases
Deferred Foreign Income Tax Expense (Benefit)
Foreign
Loss from operations
Operating Income (Loss)
Other segment (income) expenses
Initial term of agreement
Initial Term Of Agreement
Initial term of agreement.
Accumulated Deficit
Retained Earnings [Member]
Series B and C Convertible Preferred Stock
Series B And C Convertible Preferred Stock [Member]
Series B and C convertible preferred stock.
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense
Rekha Hemrajani [Member]
Rekha Hemrajani.
Rekha Hemrajani
Issuance costs
Payments of offering costs
Underwriting discounts and commissions paid
Payments of Stock Issuance Costs
Weighted average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Lease liabilities: non-current
Operating Lease, Liability, Noncurrent
Level 1
Fair Value, Inputs, Level 1 [Member]
Class Of Stock [Line Items]
Class of Stock [Line Items]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Components of Lease Costs
Lease, Cost [Table Text Block]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Auditor Location
Auditor Location
Lease ROU assets
Deferred Tax Liabilities Lease Right Of Use Assets
Deferred tax liabilities lease right of use assets.
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Commitments and Contingencies.
Renewal periods of agreement
Renewal Periods Of Agreement
Renewal periods of agreement.
Summary of Outstanding Potentially Dilutive Securities Were Excluded from Computation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Corporate Debt Securities
Corporate Debt Securities [Member]
Income Tax Authority
Income Tax Jurisdiction [Domain]
Debt Securities, Available-for-Sale [Table]
Entity Interactive Data Current
Entity Interactive Data Current
Silicon valley bank and west river loan agreement.
Silicon Valley Bank and West River Loan Agreement [Member]
SVB-WestRiver Loan Agreement
Income Statement Location
Statement of Income Location, Balance [Domain]
Operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Furniture and Fixtures
Furniture and Fixtures [Member]
Convertible shares converted in to common stock
Convertible Preferred Stock, Shares Issued upon Conversion
Accretion (Amortization) of Discounts and Premiums, Investments
Net accretion of discounts on investments
Long-term Prepaid Contract Manufacturing Costs
Prepaid Contract Manufacturing Costs [Member]
Prepaid contract manufacturing costs.
Other non-current liabilities
Increase (Decrease) in Other Noncurrent Liabilities
Lease operating lease commencement period
Lease Operating Lease Commencement Period
Lease operating lease commencement period.
Tax credits, Expiration Years
Tax Credit Carryforward Expiration Period
Tax credit carryforward expiration period.
Deferred tax liabilities:
Components of Deferred Tax Liabilities [Abstract]
Commercial License Agreement
Commercial License Agreement [Member]
Commercial license agreement.
Entity Tax Identification Number
Entity Tax Identification Number
Warrants to purchase of common stock
Warrants to purchase Shares of common stock
Warrants to purchase shares of common stock.
Tranche A.
Tranche A [Member]
Tranche A
ORGANIZATION
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Local Phone Number
Local Phone Number
Master Service Agreement
Master Service Agreement [Member]
Master service agreement.
Accrued expenses due
Payable and accrued liabilities due to related party
Other current liabilities
Short-Term Lease, Cost
Short-term lease cost
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Auditor Opinion [Text Block]
Auditor Opinion
Accounting Policies [Abstract]
Numerator:
Net Income (Loss) Attributable to Parent [Abstract]
Schedule of Components of Other Assets, Net
Schedule of Other Assets, Noncurrent [Table Text Block]
Office and Laboratory Space Located In Palo Alto, California
Office And Laboratory Space One [Member]
Office And Laboratory Space One.
Other General And Administrative Costs [Member]
Other general and administrative costs.
Other General and Administrative Costs
Cash and Cash Equivalents [Member]
Cash Equivalents
Class of Stock
Class of Stock [Domain]
Shares Available to Grant Balance
Shares Available to Grant Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Granted new options to purchase, shares
Unrecognized share-based compensation expense, weighted-average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Schedule Of Stock By Class [Table]
Stock, Class of Stock [Table]
Contractual Obligation, to be Paid, Year One
Contractual Obligation, 2026
Short-term investment corporate debt securities.
Short-term Investment Corporate Debt Securities [Member]
Short Term Investment Corporate Debt Securities
Entity Emerging Growth Company
Entity Emerging Growth Company
Other Research Costs [Member]
Other research costs.
Other Research Costs