101 - Document - Cover link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Condensed Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) link:calculationLink link:presentationLink link:definitionLink 107 - Statement - Condensed Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Organization link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Capital Structure link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Organization and summary of significant accounting policies link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Fair Value Of Financial Instruments link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Balance Sheet Components link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Term Loan link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Share-Based Compensation link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Commitments & Contingencies link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - License Agreement link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Defined Contribution Plan link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Related-Party Transactions link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Net Loss Per Share Attributable To Common Stockholders link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Organization and summary of significant accounting policies (Policies) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Organization and summary of significant accounting policies (Tables) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Fair Value Of Financial Instruments (Tables) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Balance Sheet Components (Tables) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Term Loan (Tables) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Capital Structure (Tables) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Share-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Income Taxes (Tables) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Commitments & Contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Net Loss Per Share Attributable To Common Stockholders (Tables) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Stockholders Equity - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Organization and Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Disclosure - Organization and Summary of Significant Accounting Policies - Schedule of Useful Lives of the Property and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Fair Value of Financial Instruments - Financial Liabilities Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Fair Value of Financial Instruments - Reconciliation of Financial Liabilities Measured at Fair Value Using Level 3 Unobservable Inputs (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Fair Value of Financial Instruments - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Balance Sheet Components - Schedule of Components of Property and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Balance Sheet Components - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Balance Sheet Components - Components of Accrued Expenses and Other Current Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Term Loan - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Term Loan - Schedule of Future Payments of Principal and Interest (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Capital Structure - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Capital Structure - Common Stock Reserved for Future Issuance on Converted Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 147 - Disclosure - Capital Structure - Summary of Convertible Preferred Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Share- Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Share- Based Compensation - summary of share option activity (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Share- Based Compensation - Share-based compensation expense includes share options granted to employees and nonemployees (Detail) link:calculationLink link:presentationLink link:definitionLink 151 - Disclosure - Share- Based Compensation - Fair value of each option grant (Detail) link:calculationLink link:presentationLink link:definitionLink 152 - Disclosure - Share- Based Compensation - Summary of Founder Stock activity (Detail) link:calculationLink link:presentationLink link:definitionLink 153 - Disclosure - Income Taxes - Domestic (Ireland) and Foreign Components of Pre-Tax Loss (Detail) link:calculationLink link:presentationLink link:definitionLink 154 - Disclosure - Income Taxes - Schedule of Provision for Income Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 155 - Disclosure - Income Taxes - 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Disclosure - License Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 163 - Disclosure - Related-Party Transactions - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 164 - Disclosure - Net Loss Per Share Attributable to Common Stockholders - Computation of Basic and Diluted Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 165 - Disclosure - Net Loss Per Share Attributable to Common Stockholders - Summary of Outstanding Potentially Dilutive Securities Were Excluded from Computation of Diluted Net Loss Per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 166 - Disclosure - Net Loss Per Share Attributable to Ordinary Shareholders and Unaudited ProForma Net Loss Per Share - Computation of Unaudited ProForma Basic and Diluted Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 167 - Disclosure - Organization - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 168 - Disclosure - Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink